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对颗粒酶多种不同功能的理解迎来复兴了吗？

A renaissance in understanding the multiple and diverse functions of granzymes?

作者信息

Trapani Joseph A, Bird Phillip I

机构信息

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

出版信息

Immunity. 2008 Nov 14;29(5):665-7. doi: 10.1016/j.immuni.2008.10.002.

DOI:10.1016/j.immuni.2008.10.002

PMID:19006688

Abstract

In this issue of Immunity, Metkar et al. (2008) present evidence that granzyme A plays a role in inflammatory signaling and that contrary to previous studies, it is incapable of inducing target cell death. The work challenges us to reconsider the broader biological roles of all the granzymes.

摘要

在本期《免疫》杂志中，梅特卡尔等人（2008年）提供了证据，表明颗粒酶A在炎症信号传导中起作用，并且与先前的研究相反，它无法诱导靶细胞死亡。这项工作促使我们重新思考所有颗粒酶更广泛的生物学作用。