抑郁症中的局部一致性及其与不同抑郁症状群的关系：一项静息态功能磁共振成像研究
Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study.
作者信息
Yao Zhijian, Wang Li, Lu Qing, Liu Haiyan, Teng Gaojun
机构信息
Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China.
出版信息
J Affect Disord. 2009 Jun;115(3):430-8. doi: 10.1016/j.jad.2008.10.013. Epub 2008 Nov 12.
BACKGROUND
Using a newly reported regional homogeneity (ReHo) approach, we were to explore the features of brain activity of patients with major depressive disorder (MDD) in resting state, and further to examine the relationship between abnormal brain activity of depressed patients and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD).
METHODS
22 patients with MDD and 22 gender-, age-, and education-matched healthy subjects participated in the fMRI scans.
LIMITATION
The influence of antidepressant medication to the brain activity of depressed patients was not fully excluded.
CONCLUSIONS
Our findings indicated abnormal brain activity was distributed extensively in depressed patients during resting state, and some symptom domains of depression are separately related to specific abnormal patterns of brain activity.
背景
采用最新报道的局部一致性（ReHo）方法，我们旨在探索重度抑郁症（MDD）患者静息状态下的脑活动特征，并进一步研究抑郁症患者异常脑活动与汉密尔顿抑郁量表（HRSD）评分得出的特定症状群之间的关系。
方法
22例MDD患者和22例性别、年龄和教育程度相匹配的健康受试者参与了功能磁共振成像扫描。
局限性
未完全排除抗抑郁药物对抑郁症患者脑活动的影响。
结论
我们的研究结果表明，抑郁症患者在静息状态下脑活动异常广泛分布，且抑郁症的某些症状领域分别与特定的脑活动异常模式相关。
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