巴西样本中的凝血因子VIII：C、ABO血型及黑人血统混合情况

Factor VIII:C, ABO blood groups, and black admixture in a Brazilian sample.

作者信息

Lima A M, Azevêdo E S

机构信息

Departamento de Medicina Preventiva, Universidade Federal da Bahia, Salvador, Brazil.

出版信息

Hum Biol. 1991 Feb;63(1):77-83.

PMID:1900803

Abstract

The effects of ABO blood groups and black admixture on the level of factor VIII:C are studied in healthy adults from Salvador, Bahia, Brazil. A racially mixed sample of 125 males was selected as follows: 25 whites, 25 light mulattoes, 25 medium mulattoes, 25 dark mulattoes, and 25 blacks. Levels of both factor VIII:C and K-PTT followed normal distributions. O blood group subjects showed lower factor VIII:C levels (110.20 +/- 30.76%) than non-O blood group members (135.24 +/- 31.42%) (t123 = 4.47; p less than 0.0001) and higher K-PTT levels (37.69 +/- 4.57 s) than non-O blood group subjects (35.25 +/- 3.82 s) (t123 = 3.24; p less than 0.01). By holding ABO blood type constant, there is a significant racial effect (white) on lowering the factor VIII:C level within both blood group O (t43 = 2.23; p less than 0.05) and non-O (t36 = 3.44; p less than 0.002). There is no interaction effect of race and blood group (F = 0.19; p greater than 0.6) on the factor VIII:C levels.

摘要

在巴西巴伊亚州萨尔瓦多市的健康成年人中，研究了ABO血型和黑人血统混合比例对凝血因子VIII:C水平的影响。选取了125名男性的种族混合样本，具体如下：25名白人、25名浅肤色混血儿、25名中等肤色混血儿、25名深肤色混血儿和25名黑人。凝血因子VIII:C水平和活化部分凝血活酶时间（K-PTT）均呈正态分布。O血型受试者的凝血因子VIII:C水平（110.20±30.76%）低于非O血型者（135.24±31.42%）（t123 = 4.47；p＜0.0001），且K-PTT水平（37.69±4.57秒）高于非O血型受试者（35.25±3.82秒）（t123 = 3.24；p＜0.01）。在保持ABO血型不变的情况下，种族（白人）对降低O血型组（t43 = 2.23；p＜0.05）和非O血型组（t36 = 3.44；p＜0.002）的凝血因子VIII:C水平均有显著影响。种族和血型对凝血因子VIII:C水平没有交互作用（F = 0.19；p＞0.6）。