通过检测泰国一个 former leprosy colony 居民的 PGL - 1 抗体水平评估亚临床麻风感染情况。 （注：这里“former leprosy colony”直译为“前麻风病聚居地”，具体含义可能需结合上下文进一步明确，比如可能是曾经有麻风病人集中居住、治疗或研究的特定区域等。）
Assessment of subclinical leprosy infection through the measurement of PGL-1 antibody levels in residents of a former leprosy colony in Thailand.
作者信息
Kampirapap Kowit
机构信息
Raj Pracha Samasai Institute, Department of Disease Control, Tiwanon Road, Muang District, Nonthaburi 11000, Thailand.
出版信息
Lepr Rev. 2008 Sep;79(3):315-9.
OBJECTIVES
To investigate the hypothesis that there is continuing subclinical M. leprae infection, contributing to ongoing transmission of leprosy in Phra-Pradaeng Colony.
DESIGN
A sero-epidemiological survey was carried out in Phra-Pradaeng Colony, Thailand between May and August 2005. The clinical and serological examinations were conducted in 398 people, aged 3-84 years (average 50 years), comprising 196 males and 202 females.
RESULTS
Measurement of serum anti PGL-I antibodies in eligible contacts and ex-patients showed that 18 people (4.5%) were seropositive, six people (1.5%) were strongly positive and 374 people (94.0%) were seronegative. All six people who were strongly seropositive were ex-patients; five of them had no evidence of active leprosy but the sixth person had relapsed BL leprosy with a reversal reaction.
CONCLUSIONS
This study failed to confirm the hypothesis that there was ongoing subclinical M. leprae infection. More appropriate diagnostic methods and a total survey of the colony should be considered to further clarify this problem.
目的
调查以下假说，即存在持续的亚临床麻风杆菌感染，这导致了帕拉登殖民地麻风病的持续传播。
设计
2005年5月至8月在泰国帕拉登殖民地开展了一项血清流行病学调查。对398名年龄在3至84岁（平均50岁）的人进行了临床和血清学检查，其中包括196名男性和202名女性。
结果
对符合条件的接触者和既往患者的血清抗酚糖脂-I抗体检测显示，18人（4.5%）血清呈阳性，6人（1.5%）强阳性，374人（94.0%）血清呈阴性。所有6名血清强阳性者均为既往患者；其中5人无活动性麻风病证据，但第6人复发了界线类麻风并伴有逆向反应。
结论
本研究未能证实存在持续亚临床麻风杆菌感染这一假说。应考虑采用更合适的诊断方法并对该殖民地进行全面调查，以进一步阐明这一问题。
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