23价肺炎球菌多糖疫苗对β地中海贫血无脾受试者中7价结合疫苗诱导的免疫启动的影响。
The effect of 23-valent pneumococcal polysaccharide vaccine on immunological priming induced by 7-valent conjugate vaccine in asplenic subjects with beta-thalassemia.
作者信息
Orthopoulos George V, Theodoridou Maria C, Ladis Vasilis A, Tsousis Dimitris K, Spoulou Vana I
机构信息
1st Department of Pediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Thivon and M. Asias St., Goudi, 11527 Athens, Greece.
出版信息
Vaccine. 2009 Jan 14;27(3):350-4. doi: 10.1016/j.vaccine.2008.10.070. Epub 2008 Nov 14.
The effect of the 23-valent pneumococcal polysaccharide vaccine (PPV) on the 7-valent conjugate (PCV) vaccine-induced priming was evaluated in 35 splenectomised beta-thalassemics [median (range) age: 30 (12-41) years] vaccinated with either PCV/PPV or two PCVs 1 month apart, followed by a PPV booster 12 months later. 28/35 had already received 1-3 PPVs in the past. Different schedules induced similar anamnestic responses; however priming for 3/5 serotypes induced by one or two PCVs, was inferior in subjects who had received > or =2 PPVs in the past when compared with 23 aged-matched PPV-naïve beta-thalassemics. One PPV following PCV does not affect PCV priming; multiple PPVs induce hyporesponsiveness for some serotypes in splenectomised subjects with beta-thalassemia.
在35名接受脾切除术的β地中海贫血患者[年龄中位数（范围）：30（12 - 41）岁]中评估了23价肺炎球菌多糖疫苗（PPV）对7价结合疫苗（PCV）诱导的初次免疫的影响，这些患者分别接种PCV/PPV或间隔1个月接种两剂PCV，随后在12个月后接种PPV加强针。35名患者中有28名过去已接种过1 - 3剂PPV。不同的接种方案诱导了相似的回忆反应；然而，与23名年龄匹配、未接种过PPV的β地中海贫血患者相比，过去接受过≥2剂PPV的患者中，由一剂或两剂PCV诱导的针对3/5种血清型的初次免疫反应较差。PCV后接种一剂PPV不影响PCV的初次免疫；多次接种PPV会使脾切除的β地中海贫血患者对某些血清型产生低反应性。
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