侵袭性真菌感染中抗真菌药物的序贯治疗：作用机制的重要性

Sequential prescription of antifungals in invasive fungal infection: the importance of mechanism of action.

作者信息

Candel F J, Matesanz M, Mensa J

机构信息

Department of Clinical Microbiology, Hospital Clinico San Carlos, Madrid, Spain.

出版信息

Int J Antimicrob Agents. 2008 Nov;32 Suppl 2:S133-5. doi: 10.1016/S0924-8579(08)70014-1.

DOI:10.1016/S0924-8579(08)70014-1

PMID:19013337

Abstract

The success rate of salvage therapy in invasive fungal infection is ~50%. These results have justified the use of combinations of antifungals to improve pharmacokinetic and pharmacodynamic performance and to avoid clinical antagonism. This review examines the sequence of introduction of antifungal agents as a means of avoiding this antagonism. It also analyses the possible inclusion of other drugs, such as calcineurin inhibitors or iron chelators, that can boost antifungal activity.

摘要

侵袭性真菌感染挽救治疗的成功率约为50%。这些结果证明联合使用抗真菌药物以改善药代动力学和药效学性能并避免临床拮抗作用是合理的。本综述探讨了抗真菌药物的引入顺序，以此作为避免这种拮抗作用的一种方法。它还分析了可能加入其他药物（如钙调神经磷酸酶抑制剂或铁螯合剂）以增强抗真菌活性的情况。