Agrawal Shakti K, Rittey Christopher D, Harrower Neil A, Goddard John M, Mordekar Santosh R
Department of Paediatric Neurology, Sheffield Children's Hospital, Sheffield, UK.
Dev Med Child Neurol. 2009 Jul;51(7):557-62. doi: 10.1111/j.1469-8749.2008.03181.x. Epub 2008 Nov 19.
The aim of the present study was to review the history, clinical course, treatment, and outcome of movement disorders in children and young people with complex regional pain syndrome (CRPS). Case notes were reviewed retrospectively of children and young people who presented with movement disorders in CRPS to our tertiary paediatric pain service over a period of 13 years. Ten children with CRPS presented with movement disorders (eight females, two males). The age at first presentation with symptoms of CRPS ranged from 8 to 15 years (mean 11 y 2 mo, median 13 y). The most common movement disorder was dystonia (n=8), followed by tremors (n=3) and myoclonus (n=3); two patients had all three movement disorders. The movement disorder affected mainly the lower limb (n=9) with a predilection for the foot (n=7) and was frequently initiated by minor trauma (n=7). Follow-up ranged from 6 months to 14 years. The outcome was variable, with good prognosis in nearly half of the cases: four children experienced complete resolution of symptoms. Two children showed a slight improvement. Four children showed no improvement. Movement disorders in CRPS are under-recognized in children. The management has to be multidisciplinary with an expertise in paediatric pain.
本研究的目的是回顾复杂区域疼痛综合征(CRPS)患儿和青少年运动障碍的病史、临床病程、治疗及预后。回顾性分析了13年间在我们三级儿科疼痛门诊就诊的CRPS合并运动障碍的儿童和青少年的病历。10例CRPS患儿出现运动障碍(8例女性,2例男性)。首次出现CRPS症状的年龄为8至15岁(平均11岁2个月,中位数13岁)。最常见的运动障碍是肌张力障碍(n = 8),其次是震颤(n = 3)和肌阵挛(n = 3);2例患者出现了所有三种运动障碍。运动障碍主要影响下肢(n = 9),以足部为主(n = 7),且常由轻微创伤引发(n = 7)。随访时间为6个月至14年。预后各不相同,近半数病例预后良好:4例患儿症状完全缓解。2例患儿稍有改善。4例患儿无改善。CRPS患儿的运动障碍未得到充分认识。治疗必须多学科协作,且需具备儿科疼痛方面的专业知识。