[颈动脉颅外段狭窄手术及支架置入术后的认知功能]
[Cognitive functions after surgery and stenting for extracranial stenosis of the carotid artery].
作者信息
Jansen C, Ringleb P, Böckler D, Hartmann M, Hacke W
机构信息
Neurologische Klinik, Klinikum der Ruprecht-Karls-Universität, Im Neuenheimer Feld 400, 69120, Heidelberg.
出版信息
Nervenarzt. 2008 Dec;79(12):1424, 1426-8, 1430-1. doi: 10.1007/s00115-008-2600-5.
BACKGROUND
This prospective, controlled, randomised study evaluates differences concerning cognitive functions between carotid endarterectomy (CEA) and stent-protected angioplasty (CAS) as a treatment for symptomatic carotid stenosis. Both techniques include risks whose effect on neuropsychological abilities remains yet unknown.
METHODS
Twenty-seven patients suffering from high-grade symptomatic carotid stenosis underwent neuropsychological testing before, 1 month, and 6 months after treatment. After the first testing patients were randomly assigned for CEA (n=10) or CAS (n=17) as treatment. The patients' cognitive functions were compared to those of 13 healthy controls.
RESULTS
Whether patients underwent CEA or CAS made no difference in the neuropsychological outcome 4 weeks and 6 months after treatment. Patients always performed worse than the healthy controls.
CONCLUSION
Both techniques seem to have no different effect on cognitive functions.
背景
这项前瞻性、对照、随机研究评估了颈动脉内膜切除术（CEA）和支架置入保护下血管成形术（CAS）作为有症状颈动脉狭窄治疗方法时在认知功能方面的差异。两种技术都存在风险，其对神经心理能力的影响尚不清楚。
方法
27例患有重度有症状颈动脉狭窄的患者在治疗前、治疗后1个月和6个月接受了神经心理测试。首次测试后，患者被随机分配接受CEA（n = 10）或CAS（n = 17）治疗。将患者的认知功能与13名健康对照者的认知功能进行比较。
结果
患者接受CEA还是CAS治疗，在治疗后4周和6个月的神经心理结果上没有差异。患者的表现始终比健康对照者差。
结论
两种技术似乎对认知功能没有不同影响。
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