Cox-2等位基因变异对非裔美国人结肠直肠腺瘤发生风险的保护作用。
Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.
作者信息
Ashktorab Hassan, Tsang Shirley, Luke Brian, Sun Zhonghe, Adam-Campbell Lucile, Kwagyan John, Poirier Richard, Akter Shahina, Akhgar Ahmad, Smoot Duane, Munroe David J, Ali Iqbal Unnisa
机构信息
Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, D.C., USA.
出版信息
Anticancer Res. 2008 Sep-Oct;28(5B):3119-23.
BACKGROUND
Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development.
PATIENTS AND METHODS
We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used.
RESULTS
Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3' flanking region downstream from the poly A signals (OR=0.39; CI=0.18-0.83;p=0.01) and the risk for colorectal adenoma development.
CONCLUSION
The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.
背景
最近的证据表明，Cox-2基因中的单核苷酸多态性（SNP）可能会调节结直肠腺瘤发生的风险。
患者与方法
在一项非裔美国人病例对照研究中，我们探讨了Cox-2基因多态性与腺瘤发生风险之间的可能关联，该研究包括72例晚期腺瘤患者和146例无息肉对照者。采用了一种详尽的方法，对分布在整个COX-2基因上的13个单倍型标签SNP（htSNP）进行基因分型。
结果
在内含子5中5229G>T多态性的杂合基因型[比值比（OR）=0.42；置信区间（CI）=0.19 - 0.92；p = 0.03]以及聚腺苷酸信号下游3'侧翼区域中10935A>G多态性（OR = 0.39；CI = 0.18 - 0.83；p = 0.01）与结直肠腺瘤发生风险之间观察到具有统计学意义的负相关。
结论
我们的初步研究数据表明，COX-2基因的等位基因变异显著影响非裔美国人群中腺瘤发生的风险。
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