Trim36/Haprin在非洲爪蟾胚胎发育过程中对体节的排列起着关键作用。
Trim36/Haprin plays a critical role in the arrangement of somites during Xenopus embryogenesis.
作者信息
Yoshigai Emi, Kawamura Shinobu, Kuhara Satoru, Tashiro Kosuke
机构信息
Graduate School of Genetic Resources Technology, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
出版信息
Biochem Biophys Res Commun. 2009 Jan 16;378(3):428-32. doi: 10.1016/j.bbrc.2008.11.069. Epub 2008 Nov 24.
The TRIM family members contain a tripartite motif (TRIM), which includes RING, B-box, and coiled-coil domains, or collectively RBCC. They have been implicated in a variety of biological processes, such as the regulation of differentiation and development, and oncogenesis. In this study, we discovered a novel function of the TRIM family in early development. We report the expression of Trim36/Haprin during Xenopus laevis early embryogenesis and its involvement in somite formation. Temporal expression analysis indicated that Trim36/Haprin was present throughout embryogenesis. Spatial expression analysis showed that its expression was mainly confined to the nervous system and a portion of the posterior somite. Morpholino-mediated knockdown of Trim36/Haprin markedly and specifically inhibited the somite formation. We conclude that Trim36/Haprin plays an important role in the arrangement of somites during their formation.
TRIM家族成员包含一个三联基序（TRIM），其中包括RING结构域、B盒结构域和卷曲螺旋结构域，统称为RBCC。它们参与了多种生物学过程，如分化、发育和肿瘤发生的调控。在本研究中，我们发现了TRIM家族在早期发育中的新功能。我们报道了Trim36/Haprin在非洲爪蟾早期胚胎发育过程中的表达及其在体节形成中的作用。时间表达分析表明，Trim36/Haprin在整个胚胎发育过程中均有表达。空间表达分析显示，其表达主要局限于神经系统和部分后体节。吗啉代介导的Trim36/Haprin敲低显著且特异性地抑制了体节形成。我们得出结论，Trim36/Haprin在体节形成过程中对体节的排列起重要作用。
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