Braud G, Battisti S, Karam G, Bouchot O, Rigaud J
Clinique urologique, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex, France.
Prog Urol. 2008 Dec;18(13):1062-7. doi: 10.1016/j.purol.2008.07.009. Epub 2008 Oct 18.
The objective of this study was to evaluate the mortality and morbidity of cystectomy and the functional results of the associated diversions in patients over the age of 75 operated for bladder cancer.
From 1988 to 2002, 37 patients (29 men and 8 women) aged between 75 to 88 years (median: 79 years) underwent radical cystectomy for bladder cancer. All patients had at least one comorbidity factor, 17 patients were classified as ASA II (45.9%) and 20 were classified as ASA III and IV (54.1%). An external urinary diversion was performed in 35 patients and orthotopic bladder replacement was performed in two patients. The mean follow-up was 21.0 months (range: 0.3-88.6). The mortality, early and late morbidity, and functional results were analyzed.
There was no intraoperative mortality and the early mortality rate was 5.4% (2/37). The early medical morbidity rate was 24.3%, essentially cardiovascular (pulmonary embolism, myocardial infarction, pulmonary edema), and the early surgical morbidity rate was 2.7%. The late morbidity rate was 27.0%, essentially corresponding to wound complications (peristomal or midline incisional hernias). In terms of functional results, a peristomal incisional hernia with stoma appliance difficulties was observed in 11.4% of patients with an external diversion. One of the two patients treated by bladder replacement performed intermittent self-catheterization and the other was continent during the day and required pads at night.
This study shows that the acceptable mortality and early and late morbidity results allow radical cystectomy to be proposed in patients over the age of 75.
本研究的目的是评估75岁以上膀胱癌手术患者膀胱切除术的死亡率和发病率以及相关改道术的功能结果。
1988年至2002年,37例年龄在75至88岁(中位数:79岁)之间的患者(29例男性和8例女性)接受了膀胱癌根治性膀胱切除术。所有患者至少有一个合并症因素,17例患者被分类为ASA II级(45.9%),20例被分类为ASA III级和IV级(54.1%)。35例患者进行了体外尿流改道,2例患者进行了原位膀胱替代术。平均随访时间为21.0个月(范围:0.3 - 88.6个月)。分析了死亡率、早期和晚期发病率以及功能结果。
无术中死亡,早期死亡率为5.4%(2/37)。早期内科发病率为24.3%,主要是心血管方面的(肺栓塞、心肌梗死、肺水肿),早期外科发病率为2.7%。晚期发病率为27.0%,主要对应伤口并发症(造口周围或中线切口疝)。在功能结果方面,11.4%的体外改道患者出现了伴有造口装置困难的造口周围切口疝。接受膀胱替代术治疗的2例患者中,1例进行间歇性自我导尿,另1例白天能自控排尿,夜间需要使用尿垫。
本研究表明,可接受的死亡率以及早期和晚期发病率结果使得75岁以上患者能够接受根治性膀胱切除术。