Behrooz R Dahmardeh, Sari A Esmaili, Bahramifar N, Ghasempouri S M
Department of Environmental Sciences, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Nour, Mazandaran, Iran.
Chemosphere. 2009 Feb;74(7):931-7. doi: 10.1016/j.chemosphere.2008.10.014. Epub 2008 Nov 29.
In the present study, human milk was sampled in October 2006 from Nour and Noushahr cities and their countryside on the Southern Coast of Caspian Sea, Iran. They were analyzed for organochlorine pesticides, such as dichlorodiphenyltrichloroethane (DDT) and its metabolites, hexachlorobenzene (HCB), alpha, beta and gamma-hexachlorocycloexane (HCH) isomers and six PCBs congeners (IUPAC Nos. 28, 52, 101, 138, 153 and 180). Average concentrations of HCHs, DDTs, PCBs and HCB were 3780, 2554, 1560 and 930 ng g(-1) lipid wt, respectively. There was no significant difference between the concentrations of investigated pollutants between the two cities and their countryside. No significant differences in OCPs and PCBs were found between primiparous and multiparous mothers. There was no correlation between levels of OCPs and PCBs in human milk and the age of mothers. There was a significant difference in the organochlorine levels, including DDTs, between mothers who have eaten fish once a week and those who consumed fish more than once (p>0.05). An analysis of the infant exposure to OCPs and PCBs via breast milk indicated that the daily intake rates for most of the mothers were above the guideline proposed by Health Canada which is definitely caused on children health for concern.
在本研究中，2006年10月从伊朗里海南岸的努尔市和诺沙赫尔市及其乡村采集了母乳样本。对母乳样本进行了有机氯农药分析，包括滴滴涕（DDT）及其代谢产物、六氯苯（HCB）、α、β和γ-六氯环己烷（HCH）异构体以及六种多氯联苯同系物（国际纯粹与应用化学联合会编号为28、52、101、138、153和180）。六氯环己烷、滴滴涕、多氯联苯和六氯苯的平均浓度分别为3780、2554、1560和930纳克/克脂质重量。两个城市及其乡村所调查污染物的浓度之间没有显著差异。初产妇和经产妇的母乳中有机氯农药和多氯联苯浓度没有显著差异。母乳中有机氯农药和多氯联苯的含量与母亲年龄之间没有相关性。每周吃一次鱼的母亲和吃鱼次数超过一次的母亲之间，包括滴滴涕在内的有机氯水平存在显著差异（p>0.05）。对婴儿通过母乳接触有机氯农药和多氯联苯的分析表明，大多数母亲的每日摄入量高于加拿大卫生部建议的指导值，这无疑令人担忧对儿童健康的影响。
