在有丝分裂中被抑制：Cdc20经历两次死亡。
Under arrest in mitosis: Cdc20 dies twice.
作者信息
Fry Andrew M, Yamano Hiroyuki
机构信息
Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
出版信息
Nat Cell Biol. 2008 Dec;10(12):1385-7. doi: 10.1038/ncb1208-1385.
PMID:19043431
Abstract
The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.
摘要
纺锤体组装检验点对于通过防止染色体过早分离来维持分裂细胞中的基因组完整性至关重要。在存在未附着于有丝分裂纺锤体的染色体的情况下，后期促进复合物/环体（APC/C）激活因子Cdc20的降解似乎是维持该检验点的一种基本且保守的机制。
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