一种用于阻断硫代糖苷苷元转移的武装-去武装方法。
An armed-disarmed approach for blocking aglycon transfer of thioglycosides.
作者信息
Li Zhitao, Gildersleeve Jeffrey C
机构信息
Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 USA.
出版信息
Tetrahedron Lett. 2007 Jan 22;48(4):559-562. doi: 10.1016/j.tetlet.2006.11.126.
Abstract
Thioglycosides are used frequently as glycosyl donors and as mimetics of O-glycosides. While being very useful, thioglycosides are prone to a detrimental side reaction referred to as aglycon transfer. In this paper, it is shown that aglycon transfer can be blocked by matching thioglycoside-containing acceptors with more armed glycosyl donors.
摘要
硫代糖苷经常被用作糖基供体以及O-糖苷的模拟物。硫代糖苷虽然非常有用，但容易发生一种有害的副反应，称为苷元转移。本文表明，通过将含硫代糖苷的受体与更多活性的糖基供体相匹配，可以阻止苷元转移。
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