• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries.N-乙酰-L-半胱氨酸(L-NAC)对苯乙烯诱导的耳蜗损伤的保护作用。
Acta Otolaryngol. 2009 Oct;129(10):1036-43. doi: 10.1080/00016480802566261.
2
[L-NAC protect hair cells in the rat cochlea from injury of exposure to styrene].[L-乙酰半胱氨酸保护大鼠耳蜗毛细胞免受苯乙烯暴露损伤]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Feb;25(4):176-9.
3
l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro.L- N-乙酰半胱氨酸在体外可保护外毛细胞免受肿瘤坏死因子α引发的耳毒性。
Acta Otolaryngol. 2018 Aug;138(8):676-684. doi: 10.1080/00016489.2018.1440086. Epub 2018 Mar 7.
4
Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss.苯乙烯引起的耳蜗暴露生物标志物和效应改变:听力损失的机制
Toxicol Sci. 2007 Jul;98(1):167-77. doi: 10.1093/toxsci/kfm078. Epub 2007 Apr 9.
5
Relation between outer hair cell loss and hearing loss in rats exposed to styrene.暴露于苯乙烯的大鼠外毛细胞损失与听力损失之间的关系。
Hear Res. 2008 Sep;243(1-2):28-34. doi: 10.1016/j.heares.2008.05.008. Epub 2008 May 28.
6
N-acetylcysteine attenuates noise-induced permanent hearing loss in diabetic rats.N-乙酰半胱氨酸可减轻糖尿病大鼠噪声性永久听力损失。
Hear Res. 2010 Aug;267(1-2):71-7. doi: 10.1016/j.heares.2010.03.082. Epub 2010 Apr 27.
7
A novel combination of drug therapy to protect residual hearing post cochlear implant surgery.一种用于保护人工耳蜗植入术后残余听力的新型药物联合疗法。
Acta Otolaryngol. 2016;136(4):420-4. doi: 10.3109/00016489.2015.1134809. Epub 2016 Feb 6.
8
Antioxidant treatment reduces blast-induced cochlear damage and hearing loss.抗氧化治疗可减轻爆炸引起的耳蜗损伤和听力损失。
Hear Res. 2012 Mar;285(1-2):29-39. doi: 10.1016/j.heares.2012.01.013. Epub 2012 Feb 6.
9
Is the aged rat ear more susceptible to noise or styrene damage than the young ear?老年大鼠的耳朵比年轻大鼠的耳朵更容易受到噪音或苯乙烯的损伤吗?
Noise Health. 2003 Apr-Jun;5(19):1-18.
10
Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss.水杨酸盐/N-乙酰半胱氨酸预防噪声性听力损失有效性的剂量研究。
Noise Health. 2010 Jul-Sep;12(48):159-65. doi: 10.4103/1463-1741.64972.

引用本文的文献

1
Styrene Oxide Caused Cell Cycle Arrest and Abolished Myogenic Differentiation of C2C12 Myoblasts.氧化苯乙烯导致C2C12成肌细胞的细胞周期停滞并消除其成肌分化。
J Toxicol. 2020 May 11;2020:1807126. doi: 10.1155/2020/1807126. eCollection 2020.
2
Association of organic solvents and occupational noise on hearing loss and tinnitus among adults in the U.S., 1999-2004.美国 1999-2004 年有机溶剂和职业噪声对成年人听力损失和耳鸣的关联。
Int Arch Occup Environ Health. 2019 Apr;92(3):403-413. doi: 10.1007/s00420-019-01419-2. Epub 2019 Feb 26.
3
Occupational Styrene Exposure on Auditory Function Among Adults: A Systematic Review of Selected Workers.成人职业性苯乙烯暴露对听觉功能的影响:对特定工人的系统评价
Saf Health Work. 2017 Dec;8(4):329-336. doi: 10.1016/j.shaw.2017.01.002. Epub 2017 Jan 21.
4
Emerging Therapies for Sensorineural Hearing Loss.感音神经性听力损失的新兴疗法
Otol Neurotol. 2017 Jul;38(6):792-803. doi: 10.1097/MAO.0000000000001427.

本文引用的文献

1
Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss.苯乙烯引起的耳蜗暴露生物标志物和效应改变:听力损失的机制
Toxicol Sci. 2007 Jul;98(1):167-77. doi: 10.1093/toxsci/kfm078. Epub 2007 Apr 9.
2
In vitro evaluation of oxidative damage from organic solvent vapours on human skin.有机溶剂蒸气对人体皮肤氧化损伤的体外评估。
Toxicol In Vitro. 2006 Apr;20(3):324-31. doi: 10.1016/j.tiv.2005.08.007. Epub 2005 Sep 16.
3
The ototoxicity of styrene: a review of occupational investigations.
Int Arch Occup Environ Health. 2006 Feb;79(2):93-102. doi: 10.1007/s00420-005-0030-2. Epub 2005 Sep 6.
4
Relative ototoxicity of 21 aromatic solvents.21种芳香族溶剂的相对耳毒性。
Arch Toxicol. 2005 Jun;79(6):346-54. doi: 10.1007/s00204-004-0636-2. Epub 2005 Jan 20.
5
Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol.给予苯乙烯及其代谢产物氧化苯乙烯和4-乙烯基苯酚后,小鼠肝脏和肺中谷胱甘肽消耗情况的比较。
Toxicology. 2005 Jan 31;206(3):383-8. doi: 10.1016/j.tox.2004.07.013.
6
Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons.苯乙烯7,8-氧化物可诱导神经元中的线粒体损伤和氧化应激。
Toxicology. 2004 Sep 1;201(1-3):125-32. doi: 10.1016/j.tox.2004.04.010.
7
Response of human cord blood cells to styrene exposure: evaluation of its effects on apoptosis and gene expression by genomic technology.
Toxicology. 2004 Aug 5;200(2-3):145-57. doi: 10.1016/j.tox.2004.03.021.
8
Consequences of noise- or styrene-induced cochlear damages on glutamate decarboxylase levels in the rat inferior colliculus.噪声或苯乙烯诱导的耳蜗损伤对大鼠下丘谷氨酸脱羧酶水平的影响。
Hear Res. 2004 Mar;189(1-2):83-91. doi: 10.1016/S0378-5955(03)00394-0.
9
Styrene-7,8-oxide activates a complex apoptotic response in neuronal PC12 cell line.苯乙烯-7,8-环氧化物可激活神经元PC12细胞系中的复杂凋亡反应。
Carcinogenesis. 2003 Mar;24(3):535-40. doi: 10.1093/carcin/24.3.535.
10
Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells.苯乙烯7,8-氧化物可诱导神经元细胞中的半胱天冬酶激活和规律性DNA片段化。
Brain Res. 2002 Apr 12;933(1):12-22. doi: 10.1016/s0006-8993(02)02274-6.

N-乙酰-L-半胱氨酸(L-NAC)对苯乙烯诱导的耳蜗损伤的保护作用。

Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries.

作者信息

Yang Wei Ping, Hu Bo Hua, Chen Guang Di, Bielefeld Eric C, Henderson Donald

机构信息

Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, New York 14214, USA.

出版信息

Acta Otolaryngol. 2009 Oct;129(10):1036-43. doi: 10.1080/00016480802566261.

DOI:10.1080/00016480802566261
PMID:19051069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4517195/
Abstract

CONCLUSION

Styrene exposure causes hair cell death through both apoptotic and necrotic pathways and treatment with N-acetyl-L-cysteine (L-NAC) reduces styrene ototoxicity.

OBJECTIVE

Exposure to styrene causes hearing loss and hair cell death in the middle frequency region in the cochlea. The current study was designed to examine the cell death pathways and the protective effect of L-NAC against styrene-induced cochlear injuries.

MATERIALS AND METHODS

Seventeen rats were exposed to styrene by gavage at 400 mg/kg 5 days per week for 3 weeks. Nine of the styrene-treated rats received L-NAC by intraperitoneal injection (325 mg/kg), and the remaining eight rats received saline injections as controls. The styrene-induced hearing loss was assessed by auditory brainstem responses (ABRs). Apoptotic, necrotic, and missing hair cells were quantified using combined methods, including nuclear staining with propidium iodide, F-actin staining with FITC-phalloidin, and the TUNEL assay.

RESULTS

The styrene exposure caused a threshold shift of 15±4.3 dB. Both apoptosis and necrosis were involved in the pathogenesis of the cochlear lesion, but apoptosis appeared to be the major cell death pathway leading to the styrene ototoxicity. Treatment with L-NAC reduced the number of missing and dying outer hair cells (OHCs) and reduced the styrene-induced hearing loss.

摘要

结论

苯乙烯暴露通过凋亡和坏死途径导致毛细胞死亡,而用N-乙酰-L-半胱氨酸(L-NAC)治疗可降低苯乙烯的耳毒性。

目的

接触苯乙烯会导致耳蜗中频区域听力损失和毛细胞死亡。本研究旨在探讨细胞死亡途径以及L-NAC对苯乙烯诱导的耳蜗损伤的保护作用。

材料与方法

17只大鼠每周5天经口灌胃给予400mg/kg苯乙烯,持续3周。9只经苯乙烯处理的大鼠腹腔注射L-NAC(325mg/kg),其余8只大鼠注射生理盐水作为对照。通过听性脑干反应(ABR)评估苯乙烯诱导的听力损失。使用包括碘化丙啶核染色、FITC-鬼笔环肽F-肌动蛋白染色和TUNEL检测在内的联合方法对凋亡、坏死和缺失的毛细胞进行定量。

结果

苯乙烯暴露导致阈值偏移15±4.3dB。凋亡和坏死均参与了耳蜗病变的发病机制,但凋亡似乎是导致苯乙烯耳毒性的主要细胞死亡途径。L-NAC治疗减少了缺失和死亡的外毛细胞(OHC)数量,并减轻了苯乙烯诱导的听力损失。