低剂量西多福韦联合丙磺舒治疗造血干细胞移植后BK病毒出血性膀胱炎
Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant.
作者信息
Faraci Maura, Cuzzubbo Daniela, Lanino Edoardo, Di Marco Eddi, Cirillo Carmela, Dallorso Sandro, Morreale Giuseppe, Moroni Cristina, Castagnola Elio
机构信息
Department of Haematology and Oncology, "G. Gaslini" Children Hospital, Genoa, Italy.
出版信息
Pediatr Infect Dis J. 2009 Jan;28(1):55-7. doi: 10.1097/INF.0b013e3181812cb9.
We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.
我们描述了在7例患有BK病毒相关性出血性膀胱炎的儿童中，使用1mg/kg/周的西多福韦且不联用丙磺舒的单中心儿科经验。所有病例均观察到临床改善，且无不良事件发生，尽管在完成治疗的6例患者中有5例在西多福韦治疗结束后2周观察到尿病毒载量显著降低。
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