Kobe C, Dietlein M, Mauz-Körholz C, Engert A, Borchmann P, Sabri O, Schober O, Schicha H, Kluge R
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Kerpener Str. 62, 50937 Köln, Germany.
Nuklearmedizin. 2008;47(6):235-8; quiz N75-6. doi: 10.3413/nukmed-0216.
The high negative predictive value of FDG-PET in therapy control of Hodgkin lymphoma is proven by the data acquired up to now. Thus, the analysis of the HD15 trial has shown that consolidation radiotherapy might be omitted in PET negative patients after effective chemotherapy. Further response adapted therapy guided by PET seems to be a promising approach in reducing the toxicity for patients undergoing chemotherapy. The criteria used for the PET interpretation have been standardized by the German study groups for Hodgkin lymphoma patients and will be reevaluated in the current studies.
到目前为止所获得的数据证实了氟代脱氧葡萄糖正电子发射断层扫描(FDG-PET)在霍奇金淋巴瘤治疗控制中的高阴性预测价值。因此,HD15试验的分析表明,对于化疗有效的PET阴性患者,可能无需进行巩固放疗。由PET引导的进一步适应性反应治疗似乎是一种有前景的方法,可降低接受化疗患者的毒性。德国霍奇金淋巴瘤患者研究小组已将PET解读所用的标准进行了标准化,并将在当前研究中重新评估。