Poduslo S E, Huang R, Huang J
VA Medical Center, Augusta, GA, USA.
Neurosci Lett. 2009 Feb 6;450(3):344-6. doi: 10.1016/j.neulet.2008.11.050. Epub 2008 Nov 27.
A haplotype in the gene for transient receptor potential cation channel, subfamily C, member 4 associated protein (TRPC4AP), has been identified in two extended pedigrees with late-onset Alzheimer's disease. Nine of the SNPs in the haplotype were analyzed in our unrelated Alzheimer's patients and controls. The H1 haplotype was found in 36% of the patients (199 patients) and in 26% of the controls (85 controls) (P=0.0282; OR=1.56; 95%CI=1.05-2.32). The latent classification method of analysis showed that the H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years. When clinical phenotypes were analyzed, there was a suggestion that the patients with this haplotype may have more behavioral changes and hallucinations. Moreover, both the latent classification analysis and logistic regression analysis indicated that there was no association of the haplotype with either APOE status or gender. The gene is part of a superfamily of cation channels that are involved with calcium entry into cells.
在两个患有迟发性阿尔茨海默病的扩展家系中，已鉴定出瞬时受体电位阳离子通道C亚家族成员4相关蛋白（TRPC4AP）基因中的一种单倍型。在我们的散发性阿尔茨海默病患者和对照中分析了该单倍型中的9个单核苷酸多态性。在36%的患者（199例患者）和26%的对照（85例对照）中发现了H1单倍型（P = 0.0282；比值比=1.56；95%置信区间=1.05 - 2.32）。潜在分类分析方法表明，H1单倍型是发病年龄在66至80岁之间的阿尔茨海默病患者的特征。当分析临床表型时，有迹象表明具有这种单倍型的患者可能有更多的行为改变和幻觉。此外，潜在分类分析和逻辑回归分析均表明，该单倍型与APOE状态或性别均无关联。该基因是参与钙离子进入细胞的阳离子通道超家族的一部分。
