Biezonski Dominik K, Courtemanche Andrea B, Hong Sang B, Piper Brian J, Meyer Jerrold S
Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA 01003-7710, USA.
Brain Res. 2009 Feb 3;1252:87-93. doi: 10.1016/j.brainres.2008.11.045. Epub 2008 Nov 25.
MDMA (3,4-methylenedioxymethamphetamine) is a popular recreational drug among adolescents. The present study aimed to determine the effects of repeated intermittent administration of 10 mg/kg MDMA during adolescence on behavioral (Experiment 1) and neuroendocrine (Experiment 2) responses of rats to the 5-HT(2A/2C) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and on [(3)H]ketanserin binding to 5-HT(2A) receptors. In the first experiment, MDMA pretreatment increased the frequency of head twitches and back muscle contractions, but not wet-dog shakes, to a high-dose DOI challenge. In the second experiment, both the prolactin and corticosterone responses to DOI were potentiated in MDMA-pretreated animals. No changes were found in 5-HT(2A) receptor binding in the hypothalamus or other forebrain areas that were examined. These results indicate that intermittent adolescent MDMA exposure enhances sensitivity of 5-HT(2A/2C) receptors in the CNS, possibly through changes in downstream signaling mechanisms.
摇头丸（3,4－亚甲基二氧甲基苯丙胺）是青少年中一种流行的消遣性毒品。本研究旨在确定青春期反复间歇性给予10mg/kg摇头丸对大鼠行为（实验1）和神经内分泌（实验2）反应的影响，这些反应包括对5-羟色胺（5-HT）（2A/2C）激动剂1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI）的反应以及[³H]酮色林与5-HT（2A）受体的结合。在第一个实验中，摇头丸预处理增加了高剂量DOI激发引起的头部抽搐和背部肌肉收缩频率，但不增加湿狗样抖动频率。在第二个实验中，在经摇头丸预处理的动物中，对DOI的催乳素和皮质酮反应均增强。在所检查的下丘脑或其他前脑区域，5-HT（2A）受体结合未发现变化。这些结果表明，青春期间歇性接触摇头丸可能通过下游信号机制的改变增强了中枢神经系统中5-HT（2A/2C）受体的敏感性。
