Kelley M J, Rose A Y, Keller K E, Hessle H, Samples J R, Acott T S
Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Exp Eye Res. 2009 Apr;88(4):747-51. doi: 10.1016/j.exer.2008.10.024. Epub 2008 Nov 18.
Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.
原发性开角型青光眼被认为是一种与衰老相关的疾病，研究表明衰老与小梁网（TM）细胞密度之间存在关联。人TM细胞分裂主要发生在非滤过性的前部区域。一种常用的青光眼治疗方法，即激光小梁成形术（LTP），会引发并增加这些前部TM细胞的细胞分裂以及细胞迁移。这些新分裂的迁移细胞会重新填充激光烧灼部位，这表明它们是干细胞。将讨论几项关于这种假定的TM干细胞的研究。
