Herder Christian, Brunner Eric J, Rathmann Wolfgang, Strassburger Klaus, Tabák Adam G, Schloot Nanette C, Witte Daniel R
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Düsseldorf, Germany.
Diabetes Care. 2009 Mar;32(3):421-3. doi: 10.2337/dc08-1161. Epub 2008 Dec 10.
Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up.
We measured serum IL-1Ra concentrations in a nested case-control study (181 case and 376 age-, sex-, and BMI-matched normoglycemic control subjects) within the Whitehall II cohort (U.K.).
IL-1Ra concentrations were higher in case subjects (P = 0.0006) and associated with incident type 2 diabetes (odds ratio for a 1-SD increase of IL-1Ra 1.48 [95% CI 1.21-1.80]). This association remained significant after adjustment for multiple potential confounders but was attenuated by adjusting for 2-h glucose.
Our findings indicate that individuals who will develop type 2 diabetes are characterized by a complex immune activation that also includes upregulation of the anti-inflammatory cytokine IL-1Ra.
白细胞介素-1受体拮抗剂(IL-1Ra)是白细胞介素-1β的天然抑制剂,已被证明可改善2型糖尿病患者的β细胞功能和血糖控制。本研究的目的是调查在超过10年的随访期间,IL-1Ra的基线全身水平是否与2型糖尿病的发生有关。
在英国白厅II队列的一项巢式病例对照研究(181例病例和376例年龄、性别和BMI匹配的血糖正常对照者)中,我们测量了血清IL-1Ra浓度。
病例组的IL-1Ra浓度较高(P = 0.0006),且与2型糖尿病的发生相关(IL-1Ra每增加1个标准差的比值比为1.48 [95% CI 1.21 - 1.80])。在对多个潜在混杂因素进行调整后,这种关联仍然显著,但在对2小时血糖进行调整后有所减弱。
我们的研究结果表明,即将发生2型糖尿病的个体具有复杂的免疫激活特征,其中还包括抗炎细胞因子IL-1Ra的上调。