唇疱疹的治疗与预防。
Treatment and prevention of herpes labialis.
作者信息
Opstelten Wim, Neven Arie Knuistingh, Eekhof Just
机构信息
Dutch College of General Practitioners, Utrecht, The Netherlands.
出版信息
Can Fam Physician. 2008 Dec;54(12):1683-7.
OBJECTIVE
To review the evidence regarding the treatment and prevention of herpes labialis.
QUALITY OF EVIDENCE
The evidence relating to treatment and prevention of herpes labialis is derived from randomized controlled trials (level I evidence).
MAIN MESSAGE
Treatment with an indifferent cream (zinc oxide or zinc sulfate), an anesthetic cream, or an antiviral cream has a small favourable effect on the duration of symptoms, if applied promptly. This is also the case with oral antiviral medication. If antiviral medicine (cream or oral) is started before exposure to the triggering factor (sunlight), it will provide some protection. Research on sunscreens has shown mixed results: some protection has been reported under experimental conditions that could not be replicated under natural conditions. In the long term, the number of relapses of herpes labialis can be limited with oral antiviral medication.
CONCLUSION
Only prompt topical or oral therapy will alleviate symptoms of herpes labialis. Both topical and oral treatment can contribute to the prevention of herpes labialis.
目的
回顾关于唇疱疹治疗与预防的证据。
证据质量
与唇疱疹治疗和预防相关的证据来源于随机对照试验（I级证据）。
主要信息
使用中性乳膏（氧化锌或硫酸锌）、麻醉乳膏或抗病毒乳膏进行治疗，若及时应用，对症状持续时间有轻微的有利影响。口服抗病毒药物亦是如此。如果在接触诱发因素（阳光）之前开始使用抗病毒药物（乳膏或口服），将会提供一定保护。防晒剂的研究结果不一：在实验条件下有一定保护作用，但无法在自然条件下重现。从长远来看，口服抗病毒药物可减少唇疱疹的复发次数。
结论
只有及时进行局部或口服治疗才能缓解唇疱疹症状。局部和口服治疗均有助于预防唇疱疹。
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