Kim Chul Han, Suk Ki Tae, Kim Jae Woo
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Korean J Gastroenterol. 2008 Aug;52(2):110-4.
Salmonella infection can cause an asymptomatic intestinal carrier state or clinical diseases such as enterocolitis presenting abdominal pain, fever, vomiting, or diarrhea. Salmonella usually invades Peyer's patch of terminal ileum or ascending colon. Sepsis is not common and acute renal failure secondary to rhabdomyolysis is rare. The causes of rhabdomyolysis are trauma, excessive exercise, alcohol, seizure, metabolic abnormality, and infection. Infections account for less than 5% of the reported causes of rhabdomyolysis and resulting acute renal failure. The mechanisms underlying rhabdomyolysis due to infection are direct muscle invasion, toxin production, and nonspecific effects that can occur with infections such as fever, dehydration, acidosis, and electrolyte imbalance. We report a case of sepsis and acute renal failure secondary to rhabdomyolysis associated with Salmonella infection.
沙门氏菌感染可导致无症状的肠道携带状态或临床疾病,如表现为腹痛、发热、呕吐或腹泻的小肠结肠炎。沙门氏菌通常侵袭回肠末端的派尔集合淋巴结或升结肠。败血症并不常见,继发于横纹肌溶解症的急性肾衰竭也很罕见。横纹肌溶解症的病因包括创伤、过度运动、酒精、癫痫发作、代谢异常和感染。感染在横纹肌溶解症及由此导致的急性肾衰竭的报告病因中所占比例不到5%。感染导致横纹肌溶解症的潜在机制包括直接侵袭肌肉、产生毒素以及诸如发热、脱水、酸中毒和电解质失衡等感染可能出现的非特异性效应。我们报告一例继发于与沙门氏菌感染相关的横纹肌溶解症的败血症和急性肾衰竭病例。