Nannini Margherita, Pantaleo Maria Abbondanza, Maleddu Alessandra, Astolfi Annalisa, Formica Serena, Biasco Guido
Department of Hematology and Oncology sciences "L. A. Seragnoli", Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Cancer Treat Rev. 2009 May;35(3):201-9. doi: 10.1016/j.ctrv.2008.10.006. Epub 2008 Dec 9.
Nowadays molecular biology represents one of the most interesting topics in medical oncology, because it provides a global and detailed view on the molecular changes involved in tumour progression, leading to a better understanding of the carcinogenesis process, to discovering new prognostic markers and novel therapeutic targets. The gene expression profiling analysis with microarray technology has shown a great potential in cancer research and in medical oncology, mapping simultaneously the expression of thousands of genes in a single tumour sample and giving a measurement of articulated genes expression patterns. Colorectal cancer represents a wide and exciting area of research for molecular biology, due to the growing need of a molecular classification as well as prognostic and predictive molecular factors that may guide oncologists in patient's clinical management. The aim of this review is to analyze the state of art of gene expression profile in colorectal cancer using microarrays technologies and to explore some perspectives in this research field.
如今，分子生物学是医学肿瘤学中最有趣的话题之一，因为它提供了肿瘤进展过程中分子变化的全局和详细视图，有助于更好地理解致癌过程，发现新的预后标志物和新型治疗靶点。利用微阵列技术进行的基因表达谱分析在癌症研究和医学肿瘤学中显示出巨大潜力，可同时绘制单个肿瘤样本中数千个基因的表达图谱，并测量复杂的基因表达模式。由于对分子分类以及可能指导肿瘤学家进行患者临床管理的预后和预测分子因素的需求不断增加，结直肠癌成为分子生物学研究的一个广泛且令人兴奋的领域。本综述旨在分析使用微阵列技术的结直肠癌基因表达谱的现状，并探讨该研究领域的一些前景。
