Thomaes Kathleen, Dorrepaal Ethy, Draijer Nel P J, de Ruiter Michiel B, Elzinga Bernet M, van Balkom Anton J, Smoor Paulien L M, Smit Johannes, Veltman Dick J
GGZ Buitenamstel, Amsterdam, The Netherlands.
Psychiatry Res. 2009 Jan 30;171(1):44-53. doi: 10.1016/j.pscychresns.2008.03.003. Epub 2008 Dec 11.
To gain insight into memory disturbances in Complex Posttraumatic Stress Disorder (Complex PTSD), we investigated declarative memory function and medial temporal lobe activity in patients and healthy non-traumatized controls. A case-control study was performed in nine patients with Complex PTSD and nine controls. All respondents performed a declarative memory task with neutral and emotional, negative words during functional magnetic resonance imaging. Memory performance of neutral words was impaired in Complex PTSD with a relative conservation of recall of negative words. Deep encoding of later remembered negative words, as well as correct recognition of negative words and false alarms, was associated with an enhanced Blood Oxygenation Level Dependent (BOLD) response in the left hippocampus extending into the parahippocampal gyrus of Complex PTSD patients compared with controls. Post-hoc volumetric comparisons did not reveal significant anatomical differences in the medial temporal lobe between Complex PTSD patients and controls. We conclude that in Complex PTSD preferential recall of negative words is associated with increased activation in the left hippocampus and parahippocampal gyrus during both successful and false recall. These findings support a model of an abnormally functioning hippocampus in Complex PTSD.
为深入了解复杂创伤后应激障碍（Complex PTSD）中的记忆障碍，我们对患者及健康未受创伤的对照者的陈述性记忆功能和内侧颞叶活动进行了研究。对9名复杂创伤后应激障碍患者和9名对照者进行了一项病例对照研究。所有受试者在功能磁共振成像期间执行一项使用中性和情感性负面词汇的陈述性记忆任务。复杂创伤后应激障碍患者对中性词汇的记忆表现受损，而对负面词汇的回忆相对保留。与对照者相比，复杂创伤后应激障碍患者中后来记住的负面词汇的深度编码以及对负面词汇的正确识别和错误警报，与左海马体延伸至海马旁回的血氧水平依赖（BOLD）反应增强有关。事后体积比较未发现复杂创伤后应激障碍患者与对照者在内侧颞叶存在显著的解剖学差异。我们得出结论，在复杂创伤后应激障碍中，无论是成功回忆还是错误回忆，对负面词汇的优先回忆都与左海马体和海马旁回的激活增加有关。这些发现支持了复杂创伤后应激障碍中海马体功能异常的模型。
