SHI Zhan, HE Qing-yong, HUA Bao-jin
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China.
Chin J Integr Med. 2008 Dec;14(4):257-61. doi: 10.1007/s11655-008-0257-3. Epub 2008 Dec 12.
To observe the clinical efficacy of Xiaoshui decoction (XSD) combined with intrapleural perfusion of cisplatin in the treatment of malignant pleural effusion.
Fifty-one patients with malignant pleural effusion were randomly assigned to two groups. The treated group (26 patients) received oral administration of XSD combined with intrapleural perfusion of cisplatin, and the control group (25 patients) was only treated with intrapleural perfusion of cisplatin. The effects of the short-term efficacy, quality of life scores and clinical symptom scores of malignant pleural effusion were evaluated.
The short-term efficacy in the treated group and the control group was 72.0% and 58.3%, respectively, and no significant difference was found (P>0.05). In contrast, the quality of life in the treated group was significantly improved compared to that of the control group (P<0.05), and so was the symptom remission (P<0.05).
The combined therapy of XSD and intrapleural perfusion of cisplatin did not show obvious improvement in short-term efficacy, but the therapy remarkably alleviated the symptoms and improved the quality of life of patients.
观察消水汤（XSD）联合顺铂胸腔灌注治疗恶性胸腔积液的临床疗效。
将51例恶性胸腔积液患者随机分为两组。治疗组（26例）口服消水汤联合顺铂胸腔灌注，对照组（25例）仅采用顺铂胸腔灌注治疗。评估两组对恶性胸腔积液的近期疗效、生活质量评分及临床症状评分的影响。
治疗组和对照组的近期有效率分别为72.0%和58.3%，差异无统计学意义（P>0.05）。相比之下，治疗组患者的生活质量较对照组显著改善（P<0.05），症状缓解情况亦是如此（P<0.05）。
消水汤联合顺铂胸腔灌注治疗在近期疗效上未显示出明显改善，但该疗法显著缓解了患者症状，提高了患者生活质量。
