Konno C, Fujimoto S, Shrestha R D, Kokubun M, Kobayashi K, Kiuchi S, Takahashi M, Ohta M
First Dept. of Surgery, School of Medicine, Chiba University.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1804-7.
Right after surgery, intra-peritoneal hyperthermic perfusion (IPHP) was performed under hypothermic general anesthesia for 41 gastric cancer patients with peritoneal dissemination or serosal invasion. The control group consisted of 40 patients given surgery alone. With respect to the direct antitumor efficacy of IPHP, there were no cancer cells in the peritoneal lavage from Douglas' pouch and, ascitic effusion disappeared in all patients with peritoneal dissemination. The 1- and 3-year survival rates for the IPHP group were 68% and 39%, whereas those of the control group were 30% and 0%, respectively. The survival rates for the IPHP group were better than those for the control group, with a statistically significant difference of p = 8.1 x 10(-7). As to prevention of recurrence, the incidence of peritoneal dissemination for the IPHP group was lower at p = 0.002 than the control group.
术后立即在低温全身麻醉下对41例伴有腹膜播散或浆膜侵犯的胃癌患者进行腹腔热灌注（IPHP）。对照组由40例仅接受手术的患者组成。关于IPHP的直接抗肿瘤疗效，Douglas窝的腹腔灌洗中未发现癌细胞，所有腹膜播散患者的腹水均消失。IPHP组的1年和3年生存率分别为68%和39%，而对照组分别为30%和0%。IPHP组的生存率高于对照组，p = 8.1 x 10(-7)，差异具有统计学意义。在预防复发方面，IPHP组腹膜播散的发生率低于对照组，p = 0.002。
