骨髓增生异常综合征的管理：2008年更新版
Management of myelodysplastic syndromes: 2008 update.
作者信息
Scott Bart L, Estey Eli
机构信息
University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
出版信息
Oncology (Williston Park). 2008 Nov 15;22(12):1344-52.
Abstract
Myelodysplastic syndromes (MDS) are a heterogeneous collection of hematopoietic disorders characterized by low blood counts and a tendency to progress to acute myeloid leukemia. Treatment options have increased over the past 10 years, and many new agents are currently being investigated. In this article, we review the diagnosis of MDS, prognostic systems, and treatment options, including supportive care, erythropoiesis-stimulating agents, antithymocyte globulin, lenalidomide, azacitidine, decitabine, intensive chemotherapy, and hematopoietic cell transplantation.
摘要
骨髓增生异常综合征（MDS）是一组异质性造血系统疾病，其特征为血细胞计数低以及有进展为急性髓系白血病的倾向。在过去10年中，治疗选择有所增加，目前许多新型药物正在研究中。在本文中，我们综述了MDS的诊断、预后系统和治疗选择，包括支持性治疗、促红细胞生成剂、抗胸腺细胞球蛋白、来那度胺、阿扎胞苷、地西他滨、强化化疗和造血细胞移植。
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