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阿尔茨海默病与帕金森病遗传学的共性。

Commonalities in the genetics of Alzheimer's disease and Parkinson's disease.

作者信息

Grünblatt Edna

机构信息

University of Würzburg, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, Neurochemistry Laboratory, Füchsleinstr. 15, D-97080 Würzburg, Germany.

出版信息

Expert Rev Neurother. 2008 Dec;8(12):1865-77. doi: 10.1586/14737175.8.12.1865.

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases that have a tremendous impact on the lives of affected individuals. There is a great probability of developing concurrent parkinsonism in AD and vice versa than would be predicted by independent prevalence of each disease. Both diseases have genetic familial forms with a prevalence of less than 5-10%, but the majority of the cases are sporadic. Several hypotheses exist regarding the etiology of these diseases, such as oxidative stress, inflammatory processes, ubiquitin-proteasome system dysfunction, energy deficits, cell cycle deficiencies and glutamate exitotoxicities. Since diagnosis occurs in late-stage disease after neuronal loss, it decreases the opportunity for neuroprotective/neurorestorative therapies. Therefore, early and specific diagnosis is required as well as new therapy approaches for the growing burden of AD and PD.

摘要

阿尔茨海默病(AD)和帕金森病(PD)是神经退行性疾病,对受影响个体的生活产生巨大影响。与每种疾病独立患病率所预测的情况相比,AD患者并发帕金森症以及反之亦然的可能性更大。这两种疾病都有遗传家族形式,患病率低于5%-10%,但大多数病例是散发性的。关于这些疾病的病因存在多种假说,如氧化应激、炎症过程、泛素-蛋白酶体系统功能障碍、能量缺乏、细胞周期缺陷和谷氨酸兴奋性毒性。由于诊断在神经元丧失后的疾病晚期进行,这减少了神经保护/神经恢复治疗的机会。因此,对于AD和PD日益加重的负担,需要早期和特异性诊断以及新的治疗方法。

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