头孢呋辛对卡他莫拉菌（布兰汉菌）的体外活性

[In vitro activity of cefuroxime against Moraxella (Branhamella) catarrhalis].

作者信息

Laurans G, Gaudio F, Ducroix J P, Orfila J

机构信息

Laboratoire de Bactériologie-Immunologie Générale, Centre Hospitalo-Universitaire d'Amiens.

出版信息

Pathol Biol (Paris). 1991 May;39(5):391-5.

PMID:1909016

Abstract

Minimal inhibitory concentrations of cefuroxime were determined by an agar dilution procedure and compared with erythromycin and four other beta-lactam antibiotics (amoxycillin, amoxycillin + clavulanate, cefadroxil, cefaclor) on 76 strains of Moraxella (Branhamella) catarrhalis. Sixty four of them produced a beta-lactamase. Results show that the beta-lactamase of Moraxella (Branhamella) catarrhalis abrogates the activity of amoxycillin (MIC 90% = 4 mg/l) meanwhile the combination of amoxycillin-clavulanate is inhibitory at low concentration (MIC 90% = 0.25 mg/l). There are no difference in MICs between strains producing or not producing beta-lactamase with erythromycin (MIC 90% = 0.25 mg/l). All the strains evaluated in this investigation, producing or not producing beta-lactamase have MIC 90% less than or equal to 2 mg/l for cefuroxime lower than those obtained for the two other cephalosporins.

摘要

采用琼脂稀释法测定了头孢呋辛对76株卡他莫拉菌（布兰汉菌）的最低抑菌浓度，并与红霉素及其他4种β-内酰胺类抗生素（阿莫西林、阿莫西林+克拉维酸、头孢羟氨苄、头孢克洛）进行比较。其中64株产生β-内酰胺酶。结果显示，卡他莫拉菌（布兰汉菌）的β-内酰胺酶可消除阿莫西林的活性（MIC 90% = 4 mg/l），而阿莫西林-克拉维酸组合在低浓度时具有抑制作用（MIC 90% = 0.25 mg/l）。对于红霉素，产β-内酰胺酶菌株与不产β-内酰胺酶菌株的MIC无差异（MIC 90% = 0.25 mg/l）。本研究中评估的所有菌株，无论产β-内酰胺酶与否，头孢呋辛的MIC 90%均小于或等于2 mg/l，低于其他两种头孢菌素。