Michy T, Leveque J, Loussouarn D, Dravet F, Dejode M, Sagan C, Descamps P, Classe J-M
Service d'oncologie chirurgicale, centre René-Gauducheau, CRLCC Nantes, Saint-Herblain, France.
Bull Cancer. 2008 Dec;95(12):1171-5. doi: 10.1684/bdc.2008.0756.
Margin status in cervical pathology is one of most important predictive factor of recurrent disease. Even if management of surgical biopsy is standardized, quality of surgical procedure is fundamental. Frozen section can be realise in order to complete surgical procedure if margins are involved. Extemporaneous exam of endocervical margin during conservative surgery and vaginal cuff during radical surgery is a precious information for surgeon. Endocervical status for conization, parametrial and vaginal margins have been reported to be a factor predictive of residual disease. During radical trachelectomy, margins involvment of one of these three topographic zone is an important predictive factor of recurrent disease and can be an obstacle to preserve fertility.
宫颈病理学中的切缘状态是疾病复发最重要的预测因素之一。即使手术活检的操作是标准化的，手术操作的质量仍是根本。如果切缘受累，可以进行冰冻切片以完成手术。在保守手术期间对宫颈内口切缘以及在根治性手术期间对阴道断端进行即时检查，对外科医生来说是宝贵的信息。据报道，宫颈锥切术的宫颈内口状态、宫旁组织和阴道切缘是残留疾病的预测因素。在根治性宫颈切除术期间，这三个解剖区域之一的切缘受累是疾病复发的重要预测因素，并且可能成为保留生育能力的障碍。
