Schuler Christine R, Kitt Margaret M, Henneberger Paul K, Deubner David C, Kreiss Kathleen
Division of Respiratory Disease Studies, Field Studies Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa 26505, USA.
J Occup Environ Med. 2008 Dec;50(12):1343-50. doi: 10.1097/JOM.0b013e31818def24.
We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD).
We invited the cohort's participation in current worker surveys in 1992, 1998, 2000, and 2002-2003, and in former worker surveys in 2000-2001 and 2003. We calculated 11-year cumulative incidences (after 1992 initial survey) of sensitization and CBD, both crude and corrected for interval censoring; and period prevalences (including 1992 findings), crude and corrected.
In 1992, point prevalences were 6% sensitized and 4% CBD. We obtained follow-up on 83% of 128 not sensitized in 1992. Crude cumulative incidences for sensitization and CBD were 13% and 9%, respectively; corrected were 15% and 11%. Crude period prevalences for sensitization and CBD were 16% and 11%, respectively; corrected were 20% and 14%. Corrected period prevalences for pre-1992 machining work were 30% and 20%.
With repeated testing over 11 years, total sensitization and CBD in this cohort were triple initial 1992 survey results.
我们对136名氧化铍陶瓷工人进行了1992年至2003年的队列随访，包括那些离职的工人，以观察铍致敏和慢性铍病（CBD）情况。
我们邀请该队列参与1992年、1998年、2000年以及2002 - 2003年的在职工人调查，以及2000 - 2001年和2003年的离职工人调查。我们计算了致敏和CBD的11年累积发病率（1992年初始调查之后），包括粗发病率以及校正了区间删失后的发病率；还计算了时期患病率（包括1992年的调查结果），同样包括粗患病率和校正后的患病率。
1992年，致敏的时点患病率为6%，CBD为4%。我们对1992年未致敏的128人中的83%进行了随访。致敏和CBD的粗累积发病率分别为13%和9%；校正后分别为15%和11%。致敏和CBD的粗时期患病率分别为16%和11%；校正后分别为20%和14%。1992年前从事机械加工工作的校正时期患病率分别为30%和20%。
经过11年的重复检测，该队列中总的致敏和CBD发病率是1992年初始调查结果的三倍。
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