人源化严重联合免疫缺陷小鼠在人用疫苗研发中的应用。
Use of humanized severe combined immunodeficient mice for human vaccine development.
作者信息
Koo Gloria C, Hasan Aisha, O'Reilly Richard J
机构信息
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, NY 10021, USA.
出版信息
Expert Rev Vaccines. 2009 Jan;8(1):113-20. doi: 10.1586/14760584.8.1.113.
Abstract
The severe combined immunodeficient (SCID) mouse has no adaptive immunity, lacking mature T and B cells in the peripheral blood or the lymphoid organs. It has been used extensively in biomedical research as a valuable translational model for xeno-engraftment of human tissues and cells. This review focuses on the engraftment of human peripheral blood cells and tissues in SCID mice, as well as in the newly established and more permissive SCID mice deficient in the IL-2 receptor gamma-chain. Human immune responses could be elicited and assessed in these humanized SCID mice upon vaccination or sensitization with allogeneic tissues. A translational model is proposed to attain preclinical data for testing human vaccines.
摘要
严重联合免疫缺陷（SCID）小鼠没有适应性免疫，外周血或淋巴器官中缺乏成熟的T细胞和B细胞。它作为人类组织和细胞异种移植的宝贵转化模型，已在生物医学研究中广泛应用。本综述重点关注人类外周血细胞和组织在SCID小鼠以及新建立的、对IL-2受体γ链缺陷更具耐受性的SCID小鼠中的移植情况。在用同种异体组织进行疫苗接种或致敏后，可在这些人源化SCID小鼠中引发并评估人类免疫反应。提出了一种转化模型，以获取用于测试人类疫苗的临床前数据。
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2
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