[肿瘤细胞血行播散对肝细胞癌术后复发及远处转移的影响]
[The influence of tumor cells spreading in blood to relapse and distant metastasis of hepatocellular carcinoma after surgery].
作者信息
LIU Yang, ZHANG Guo-tong, WU Meng-chao
机构信息
Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2008 Oct 15;46(20):1583-5.
OBJECTIVE
To study the relationship between peripheral blood hepatocellular carcinoma cells-associated AFP mRNA and tumor relapse and metastasis.
METHODS
To detect several blood samples from the HCC patients by nested RT-PCR to find out AFP mRNA after 24 h, 72 h and one week and 4 weeks after surgery, and followed up the HCC patients for 1, 2, 3 years.
RESULTS
There were 7 patients occurred relapse or distant metastasis in 12 patients with AFP mRNA positive (7/12, 58.3%), there were 5 patients occurred relapse in 19 patients with AFP mRNA negative (5/19, 26.3%) within 1 year, there was 4 patients occurred relapse in second year (9/19, 47.3%); 5 patients occurred relapse in third year (10/19, 52.6%). Obvious connection between patients AFP mRNA positive and AFP mRNA negative was observed (P < 0.01).
CONCLUSIONS
HCC with AFP mRNA positive has more change to be recurrent compared with HCC patients with AFP mRNA negative.
目的
研究外周血中与肝细胞癌相关的甲胎蛋白信使核糖核酸（AFP mRNA）与肿瘤复发及转移的关系。
方法
通过巢式逆转录聚合酶链反应（nested RT-PCR）检测肝癌患者术后24小时、72小时、1周及4周的多份血样，以找出AFP mRNA，并对肝癌患者进行1年、2年、3年的随访。
结果
AFP mRNA阳性的12例患者中有7例出现复发或远处转移（7/12，58.3%）；AFP mRNA阴性的19例患者中，1年内有5例复发（5/19，26.3%），第2年有4例复发（9/19，47.3%），第3年有5例复发（10/19，52.6%）。观察到AFP mRNA阳性患者与AFP mRNA阴性患者之间存在明显关联（P<0.01）。
结论
与AFP mRNA阴性的肝癌患者相比，AFP mRNA阳性的肝癌患者复发的可能性更大。
Zotero 插件