水通道蛋白7和水通道蛋白9在甘油代谢中的作用；与肥胖的关系。
Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity.
作者信息
Maeda Norikazu, Hibuse Toshiyuki, Funahashi Tohru
机构信息
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Toshiyuki Hibuse Yamada-oka, Suita, Osaka, 565-0871, Japan.
出版信息
Handb Exp Pharmacol. 2009(190):233-49. doi: 10.1007/978-3-540-79885-9_12.
The discovery of aquaporin (AQP) has had a great impact on life sciences. So far, 13 AQPs have been identified in human. AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Many investigators have demonstrated that AQPs play a crucial role in maintaining water homeostasis, but the physiological significance of some AQPs as a glycerol channel has not been fully understood. Adipocyte is considered to be a major source of glycerol which is one of substrates for hepatic gluconeogenesis. This review focuses on recent studies of glycerol metabolism through AQP7 and AQP9, and discusses the importance of glycerol channel in adipose tissues and liver.
水通道蛋白（AQP）的发现对生命科学产生了重大影响。到目前为止，已在人类中鉴定出13种水通道蛋白。AQP3、7、9和10被归类为水甘油通道蛋白，它们可使甘油和水通透。许多研究人员已经证明，水通道蛋白在维持水平衡方面起着关键作用，但一些水通道蛋白作为甘油通道的生理意义尚未完全了解。脂肪细胞被认为是甘油的主要来源，甘油是肝脏糖异生的底物之一。本文综述了通过AQP7和AQP9进行甘油代谢的最新研究，并讨论了甘油通道在脂肪组织和肝脏中的重要性。
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