ETYA对PC3线粒体的靶向破坏：一种“特洛伊木马”膜自杀分子。
Targetted destruction of PC3 mitochondria by ETYA: a 'Trojan horse' membrane-suicide molecule.
作者信息
Anderson K M, Harris J E
机构信息
Department of Medicine, Rush Medical College, Chicago, IL 60612.
出版信息
Med Hypotheses. 1991 Jun;35(2):151-3. doi: 10.1016/0306-9877(91)90040-6.
PMID:1909769
Abstract
The reported incorporation of ETYA in place of arachidonic acid, itself enriched in mitochondria, and the autooxidation of alkyne groups, as indicated by spontaneous chemiluminescence, encompasses several features appropriate for an organelle-specific 'suicide' molecule. In point of fact, ETYA selectively destroys PC3 mitochondria.
摘要
据报道，用ETYA取代本身富含于线粒体中的花生四烯酸，以及炔基的自动氧化（如自发化学发光所示），包含了几个适合细胞器特异性“自杀”分子的特征。事实上，ETYA能选择性地破坏PC3线粒体。
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