Whyte Ana, Monteagudo Luis V, Díaz-Otero Angel, Lebrero M Eugenia, Tejedor M Teresa, Falceto M Victoria, Whyte Jaime, Gallego Margarita
Department of Animal Pathology, Faculty of Veterinary Sciences, 50013 Zaragoza, Spain.
Anim Reprod Sci. 2009 Oct;115(1-4):328-33. doi: 10.1016/j.anireprosci.2008.11.008. Epub 2008 Nov 20.
Persistence of the Müllerian duct syndrome (PMDS) is a rare form of pseudohermaphroditism characterized by the presence of uterus and oviducts in otherwise normally differentiated SRY-positive 78 XY canine males. Undescended testicles are also common. We report a case of a male PMDS dog with a uterus and bilateral cryptorchidism. The dog had an incomplete regression of the mesonephric tubules. As a consequence of this an abnormally enlarged head of the epididymis was observed. In addition, an extreme reduction in size of both the body and the tail was found. Microscopic examination of both testicles revealed bilateral hyperplasia of Leydig cells. The progesterone blood level was measured by ELISA and was found to be abnormally high (3.18 ng/ml) compared to that of normal male dogs (lower than 1 ng/ml). Three months after surgical removal of the internal genitalia, the serum progesterone, testosterone and oestradiol levels were normal for a castrated male dog.
苗勒管永存综合征（PMDS）是一种罕见的假两性畸形，其特征是在其他方面正常分化的SRY阳性78 XY雄性犬中存在子宫和输卵管。隐睾也很常见。我们报告一例患有子宫和双侧隐睾的雄性PMDS犬病例。该犬中肾小管不完全退化。因此，观察到附睾头部异常增大。此外，还发现附睾体部和尾部尺寸极度减小。对两个睾丸的显微镜检查显示莱迪希细胞双侧增生。通过酶联免疫吸附测定法（ELISA）测量孕酮血水平，发现与正常雄性犬相比异常高（3.18纳克/毫升）（正常雄性犬低于1纳克/毫升）。手术切除内生殖器三个月后，去势雄性犬的血清孕酮、睾酮和雌二醇水平正常。
