The University of Queensland, School of Molecular and Microbial Sciences, Chemistry Building 68, St. Lucia, Brisbane, Qld 4072, Australia.
Bioorg Med Chem Lett. 2009 Feb 1;19(3):821-4. doi: 10.1016/j.bmcl.2008.12.013. Epub 2008 Dec 7.
Group A streptococcus is a Gram-positive bacteria that causes a range of infectious diseases. Targeting the bacteria, a new self-adjuvanting vaccine candidate, incorporating a carbohydrate carrier and an amino acid-based adjuvant, was synthesised utilising carbohydrate chemistry and solid-phase peptide synthesis procedures. Characterisation of the candidate was achieved using reverse-phase HPLC and electrospray ionisation mass spectrometry. The successful synthesis and characterisation of the vaccine candidate may contribute to the discovery of a therapeutically and clinically viable vaccine against group A streptococcus.
A 组链球菌是一种革兰氏阳性细菌，可引起多种传染病。本研究利用碳水化合物化学和固相肽合成技术，针对该细菌合成了一种新型的自佐剂疫苗候选物，该候选物包含一个碳水化合物载体和一个基于氨基酸的佐剂。采用反相高效液相色谱和电喷雾电离质谱对候选物进行了表征。疫苗候选物的成功合成和表征可能有助于发现一种针对 A 组链球菌的具有治疗和临床应用价值的疫苗。
