Saarikoski S, Yliskoski M, Penttilä I
Département de Gynécologie-Obstétrique, Hôpital Universitaire Central, Kuopio, Finlande.
Rev Fr Gynecol Obstet. 1991 Jun;86(6):475-80.
A sequential treatment either with norethisterone or with oral natural micronized progesterone was administered, after randomization, to 80 women consulting for premenopausal disorders of the menstrual cycle. In all cases, the initial aspect of the endometrium showed a progesterone deficit with hyperplasia in 50 per cent of cases. At the third and sixth month of treatment, none of the biopsies presented hyperplastic characteristics whether after norethisterone or oral progesterone. However, three months after suspension of treatment, the proliferative or hyperplastic characteristics reappeared in 24 per cent of cases in the norethisterone group, and in 10 per cent of cases in the oral progesterone group. The administration of norethisterone induced a decrease in plasma levels of estradiol (E2), FSH and LH, and sex-hormone-binding globulin (SHBG) (p less than 0.001). No modification was observed during treatment with oral progesterone. The plasma levels of HDL-cholesterol and triglycerides were decreased by norethisterone (p less than 0.001-0.02). A slight decrease in phospholipids was also observed in this group. Treatment with oral natural micronized progesterone therefore offers an attractive alternative for the treatment of premenopausal menstrual disorders.
对80名因绝经前月经周期紊乱前来咨询的女性进行随机分组后，依次给予炔诺酮或口服天然微粉化孕酮治疗。在所有病例中，子宫内膜的初始状态显示孕酮缺乏，50%的病例存在增生。在治疗的第三个月和第六个月，无论是接受炔诺酮还是口服孕酮治疗，所有活检均未呈现增生特征。然而，在停药三个月后，炔诺酮组24%的病例和口服孕酮组10%的病例中，增殖或增生特征再次出现。炔诺酮的使用导致雌二醇（E2）、促卵泡生成素（FSH）、促黄体生成素（LH）和性激素结合球蛋白（SHBG）的血浆水平下降（p<0.001）。口服孕酮治疗期间未观察到变化。炔诺酮使高密度脂蛋白胆固醇和甘油三酯的血浆水平降低（p<0.001-0.02）。该组还观察到磷脂略有下降。因此，口服天然微粉化孕酮治疗为绝经前月经紊乱的治疗提供了一种有吸引力的替代方法。
