Meijerink Jules P P, den Boer Monique L, Pieters Rob
Department of Pediatric Oncology/Hematology, Erasmus Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands.
Semin Hematol. 2009 Jan;46(1):16-23. doi: 10.1053/j.seminhematol.2008.09.006.
Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.
在急性淋巴细胞白血病（ALL）中已发现众多基因异常。在此，我们回顾复发性异常，重点关注那些最近发现的异常，并讨论它们与化疗耐药性或敏感性以及治疗临床反应的关联。此外，还将讨论基因异常在白血病发生中的作用及其作为治疗靶点的潜力。
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