台湾地区胆道闭锁的肝移植：一项全国性研究。
Liver transplantation for biliary atresia in Taiwan: a national study.
作者信息
Tiao M-M, Yang C-Y, Tsai S-S, Chen C-L, Kuo H-W
机构信息
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
出版信息
Transplant Proc. 2008 Dec;40(10):3569-70. doi: 10.1016/j.transproceed.2008.07.136.
A national database for orthotopic liver transplantation (OLT) among biliary atresia (BA) cases in Taiwan has not been reported. Using the National Health Insurance (NHI) database to investigate the prognostic features of patients with BA receiving OLT, we studied the prognosis of this procedure for BA. The NHI in Taiwan covers most of the population (>99%). From 1996-2004, 106 BA patients underwent transplantation. A linear time trend analysis was performed to estimate the annual slope for BA patients to receive OLT. The rate of increase per year of 2.6 cases was significant (R(2) = .649; P = .029). The 5-year overall survival after OLT was 97.1% +/- 1.6%, which was not different between those who had or had not previously undergone portoenterostomy (94.9% vs 97.8%; P = .160). It was not different among patients undergoing transplantation during the various seasons (P = .505). Our data confirmed the effectiveness of OLT for the treatment of BA in children with or without KP in Taiwan.
台湾尚未报道过胆道闭锁（BA）病例原位肝移植（OLT）的全国性数据库。利用国民健康保险（NHI）数据库调查接受OLT的BA患者的预后特征，我们研究了该手术对BA的预后情况。台湾的NHI覆盖了大部分人口（>99%）。1996年至2004年，106例BA患者接受了移植。进行线性时间趋势分析以估计BA患者接受OLT的年斜率。每年增加2.6例的速率具有显著性（R² = 0.649；P = 0.029）。OLT术后5年总生存率为97.1%±1.6%，既往接受或未接受过肠造瘘术的患者之间无差异（94.9%对97.8%；P = 0.160）。不同季节接受移植的患者之间也无差异（P = 0.505）。我们的数据证实了OLT对台湾有无门静脉高压（KP）的儿童BA治疗的有效性。
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