使用混合的猪繁殖与呼吸综合征病毒（PRRSV）-猪圆环病毒2型（PCV2）-猪流感病毒（SIV）临床感染模型，在接种疫苗2至3个月后比较商用单剂量和双剂量PCV2疫苗的效力。
Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3-months post vaccination.
作者信息
Opriessnig T, Patterson A R, Madson D M, Pal N, Halbur P G
机构信息
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, United States.
出版信息
Vaccine. 2009 Feb 11;27(7):1002-7. doi: 10.1016/j.vaccine.2008.11.105. Epub 2008 Dec 25.
The study objectives were to compare the duration of immunity of commercially available, one and two dose, killed porcine circovirus type 2 (PCV2) vaccines. Sixty, 3.5-week-old pigs were randomly divided into six treatment groups: one dose vaccines (FDAH-1, BIVI-1), two dose vaccines (Intervet-2, FDAH-2), and non-vaccinated negative and positive controls. Tissue homogenate challenge was conducted 63 (two doses) or 84 (one dose) days post vaccination. Viremia was reduced by 78.5% in pigs vaccinated with one dose and by 97.1% in pigs vaccinated with two dose products and overall microscopic lymphoid lesions were reduced by 78.7% and 81.8%, respectively.
本研究的目的是比较市售的单剂量和双剂量猪圆环病毒2型（PCV2）灭活疫苗的免疫持续时间。60头3.5周龄仔猪被随机分为六个治疗组：单剂量疫苗组（FDAH-1、BIVI-1）、双剂量疫苗组（英特威-2、FDAH-2）以及未接种疫苗的阴性和阳性对照组。在接种疫苗后63天（双剂量组）或84天（单剂量组）进行组织匀浆攻毒。单剂量接种猪的病毒血症降低了78.5%，双剂量接种猪的病毒血症降低了97.1%，总体微观淋巴样病变分别减少了78.7%和81.8%。
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