Damen J, Hagemeijer J W, van den Broek L, Poldermans D
Universitair Medisch Centrum St Radboud, afd. Anesthesiologie, Huispost 550, Postbus 9101, 6500 HB Nijmegen.
Ned Tijdschr Geneeskd. 2008 Nov 29;152(48):2612-6.
Approximately 2.5% of the patients undergoing non-cardiac surgery suffer from perioperative cardiac complications. These are associated with a mortality of 20.60%, a longer stay in hospital and higher costs. The risk factors for perioperative cardiac complications are: high-risk surgery, ischaemic heart disease, a history of congestive heart failure, cerebrovascular disease, diabetes, and renal failure. Recently, the scope of medical management has shifted from assessing and treating underlying culprit coronary lesions toward coronary plaque stabilisation and prevention of myocardial oxygen supply demand mismatch. Currently, the prevention of cardiac problems consists of identification of the patients at risk, optimisation of the preoperatieve condition by modification of underlying risk factors, optimisation of the perioperative medication with adrenergic beta-antagonists, statins, and acetylsalicylic acid, adequate perioperative monitoring and measures to prevent myocardial ischaemia. These include adequate sedation and analgesia, adequate oxygenation, oxygen transport, and ventilation, and if necessary additional cardiac medication.
接受非心脏手术的患者中约有2.5%会发生围手术期心脏并发症。这些并发症与20.60%的死亡率、更长的住院时间和更高的费用相关。围手术期心脏并发症的危险因素包括:高风险手术、缺血性心脏病、充血性心力衰竭病史、脑血管疾病、糖尿病和肾衰竭。最近,医疗管理的范围已从评估和治疗潜在的冠状动脉病变转向冠状动脉斑块稳定化和预防心肌氧供需不匹配。目前,心脏问题的预防包括识别高危患者、通过改变潜在危险因素优化术前状况、用肾上腺素能β受体拮抗剂、他汀类药物和乙酰水杨酸优化围手术期用药、充分的围手术期监测以及预防心肌缺血的措施。这些措施包括充分的镇静和镇痛、充分的氧合、氧输送和通气,必要时使用额外的心脏药物。