Altman Daniel, Elmér Caroline, Kiilholma Pentti, Kinne Ingebjørg, Tegerstedt Gunilla, Falconer Christian
From the Department of Medical Epidemiology and Biostatistics, the Division of Obstetrics and Gynecology, and the Division of Surgery and Urology, Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden; the Department of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland; the Department of Obstetrics and Gynecology, Akershus University Hospital, University of Oslo, Lørenskog, Norway; and the Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Obstet Gynecol. 2009 Jan;113(1):127-133. doi: 10.1097/AOG.0b013e3181922362.
To estimate sexual dysfunction before and after trocar-guided transvaginal mesh surgery for pelvic organ prolapse.
Sexually active women participating in a prospective multicenter study were recruited at 26 centers. All participants underwent a standardized surgical procedure and were evaluated before (n=105) and 1 year after (n=84) surgery using the short form of the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12). Nonparametric statistics were used for comparisons.
Mean age at surgery was 61.5 years (standard deviation [SD] 7.6), median parity was 2 (range, 1-6), and mean body mass index was 26.8 (SD 4.3) (body mass index is calculated as weight (kg)/[height m]). Anterior transvaginal mesh repair was performed in 46 patients (44%), posterior in 26 patients (25%), and combined anterior and posterior in 33 patients (31%). Overall sexual function scores worsened from 15.5 (SD 8.0) at baseline to 11.7 (SD 6.9) 1 year after surgery (P<.001). The trend toward deteriorating sexual function scores was similar for all three surgical procedures. There was an overall worsening of all symptoms in the behavioral-emotive and partner-related items, whereas improvements were observed in physical function. Overall rates and severity of dyspareunia in specific neither improved nor worsened.
Sexual function scores deteriorate 1 year after trocar-guided transvaginal mesh surgery. The worsening was attributed primarily to a worsening in behavioral-emotive and partner-related items. Anatomical cure after surgery was not associated with improved PISQ scores.
ClinicalTrials.gov, www.clinicaltrials.gov, NCT00402844
II.
评估用于盆腔器官脱垂的套管针引导经阴道网片手术前后的性功能障碍情况。
在26个中心招募参与一项前瞻性多中心研究的性活跃女性。所有参与者均接受标准化手术,并在术前(n = 105)和术后1年(n = 84)使用盆腔器官脱垂/尿失禁性功能问卷简表(PISQ - 12)进行评估。采用非参数统计进行比较。
手术时的平均年龄为61.5岁(标准差[SD] 7.6),中位产次为2(范围1 - 6),平均体重指数为26.8(SD 4.3)(体重指数计算为体重(kg)/[身高m]²)。46例患者(44%)进行了经阴道前路网片修补术,26例患者(25%)进行了后路修补术,33例患者(31%)进行了前后联合修补术。总体性功能评分从基线时的15.5(SD 8.0)降至术后1年的11.7(SD 6.9)(P <.001)。所有三种手术方式的性功能评分恶化趋势相似。行为 - 情感和伴侣相关项目的所有症状总体恶化,而身体功能有所改善。特定性交困难的总体发生率和严重程度既未改善也未恶化。
套管针引导经阴道网片手术后1年性功能评分下降。这种恶化主要归因于行为 - 情感和伴侣相关项目的恶化。手术解剖学治愈与PISQ评分改善无关。
ClinicalTrials.gov,www.clinicaltrials.gov,NCT00402844
II级