肿瘤相关成纤维细胞作为抗VEGF治疗耐药的“特洛伊木马”介导者。
Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy.
作者信息
Francia Giulio, Emmenegger Urban, Kerbel Robert S
机构信息
Division of Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
出版信息
Cancer Cell. 2009 Jan 6;15(1):3-5. doi: 10.1016/j.ccr.2008.12.011.
While targeting VEGF has shown success against a number of human cancers, drug resistance has resulted in compromised clinical benefits. In this issue of Cancer Cell, Crawford et al. (2009) report that tumors resistant to anti-VEGF therapy stimulate tumor-associated fibroblasts to express proangiogenic PDGF-C, implicating it as a potential therapeutic target.
虽然靶向血管内皮生长因子（VEGF）已在多种人类癌症治疗中取得成功，但耐药性导致临床获益受损。在本期《癌细胞》杂志中，克劳福德等人（2009年）报告称，对抗VEGF治疗耐药的肿瘤会刺激肿瘤相关成纤维细胞表达促血管生成的血小板衍生生长因子C（PDGF-C），这表明它是一个潜在的治疗靶点。
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