Rusiecka-Ziółkowska Jolanta, Walszewska Monika, Stekla Julia, Szponar Bogumiła
Akademia Medyczna we Wrocławiu, Katedra i Zakład Mikrobiologii.
Pol Merkur Lekarski. 2008 Sep;25(147):260-5.
The nosocomial infections caused by Gram-negative bacteria, in this number Acinetobacter baumannii and Pseudomonas aeruginosa, have severe course and relatively high prevalence of sepsis cases. Pathomechanism of sepsis is related to activation and release of bacterial endotoxin, which is a macromolecule engaged in initiation of cytokine cascade. These mediators are responsible for heavy tissues and organs devastation. Factors that bind and neutralize endotoxin in organism are promising candidates for experimental therapy of sepsis.
由革兰氏阴性菌引起的医院感染，其中包括鲍曼不动杆菌和铜绿假单胞菌，病程严重，败血症病例的患病率相对较高。败血症的发病机制与细菌内毒素的激活和释放有关，内毒素是一种参与细胞因子级联反应启动的大分子。这些介质会导致组织和器官严重受损。在生物体中结合并中和内毒素的因素有望成为败血症实验治疗的候选药物。
