Noguchi Kyoko, Herr Deron, Mutoh Tetsuji, Chun Jerold
The Department of Molecular Biology, Helen L. Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States.
Curr Opin Pharmacol. 2009 Feb;9(1):15-23. doi: 10.1016/j.coph.2008.11.010. Epub 2008 Dec 30.
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors.
溶血磷脂酸（LPA）是一种生物活性磷脂，其同源G蛋白偶联受体家族已在神经系统的许多生物学功能中显示出作用。迄今为止，已鉴定出五种LPA受体，可能还存在其他受体。为了确定生物学和医学相关作用，这些受体中的大多数已在小鼠中被基因敲除。此外，还报道了小分子激动剂和拮抗剂。在这里，我们综述了关于LPA信号传导在神经系统功能方面的最新数据，并总结了有关LPA受体报道的激动剂和拮抗剂的数据。
