Zhao Di, Huang Wenhai, Rahaman Mohamed N, Day Delbert E, Wang Deping
Institute of Bioengineering and Information Technology Materials, Center for Advanced Materials & Nano-Biomedicine, Tongji University, Shanghai 200092, China.
Acta Biomater. 2009 May;5(4):1265-73. doi: 10.1016/j.actbio.2008.11.021. Epub 2008 Dec 10.
The effect of replacing varying amounts (0-2.5 mol.%) of B2O3 with Al2O3 in a borate glass on (1) the conversion of the glass to HA in an aqueous phosphate solution and (2) the compressive strength of the as-formed HA product was investigated. Samples of each glass (10 x 10 x 8 mm) were placed in 0.25 M K2HPO4 solution at 60 degrees C, and the conversion kinetics to HA were determined from the weight loss of the glass and the pH of the solution. The structure and composition of the solid reaction products were characterized using X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. While the conversion rate of the glass to HA decreased considerably with increasing Al2O3 content, the microstructure of the HA product became denser and the compressive strength of the HA product increased. The addition of SiO2 to the Al2O3-containing borate glass reversed the deterioration of the conversion rate, and produced a further improvement in the strength of the HA product. The compressive strength of the HA formed from the borate glass with 2.5 mol.% Al2O3 and 5 mol.% SiO2 was 11.1 +/- 0.2 MPa, which is equal to the highest strengths reported for trabecular bone. The results indicated that simultaneous additions of Al2O3 and SiO2 could be used to control the bioactivity of the borate glass and to enhance the mechanical strength of the HA product. Furthermore, the HA product formed from the glass containing both SiO2 and Al2O3 could be applied to bone repair.
研究了在硼酸盐玻璃中用Al₂O₃替代不同含量(0 - 2.5摩尔%)的B₂O₃对以下两方面的影响:(1)玻璃在磷酸盐水溶液中向羟基磷灰石(HA)的转化;(2)所形成的HA产物的抗压强度。将每种玻璃样品(10×10×8毫米)置于60℃的0.25M K₂HPO₄溶液中,根据玻璃的重量损失和溶液的pH值确定向HA的转化动力学。使用X射线衍射、傅里叶变换红外光谱和扫描电子显微镜对固体反应产物的结构和组成进行了表征。虽然随着Al₂O₃含量的增加,玻璃向HA的转化率显著降低,但HA产物的微观结构变得更致密,且HA产物的抗压强度增加。向含Al₂O₃的硼酸盐玻璃中添加SiO₂可逆转转化率的下降,并进一步提高HA产物的强度。由含2.5摩尔% Al₂O₃和5摩尔% SiO₂的硼酸盐玻璃形成的HA的抗压强度为11.1±0.2MPa,这与报道的小梁骨的最高强度相当。结果表明,同时添加Al₂O₃和SiO₂可用于控制硼酸盐玻璃的生物活性,并提高HA产物的机械强度。此外,由同时含有SiO₂和Al₂O₃的玻璃形成的HA产物可应用于骨修复。