Suppr超能文献

加州鳉鱼(Fundulus parvipinnis)体内的吸虫(Euhaplorchis californiensis)对其大脑单胺类物质的寄生操纵

Parasite manipulation of brain monoamines in California killifish (Fundulus parvipinnis) by the trematode Euhaplorchis californiensis.

作者信息

Shaw J C, Korzan W J, Carpenter R E, Kuris A M, Lafferty K D, Summers C H, Øverli Ø

机构信息

Department of Ecology, Evolution and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106-7130, USA.

出版信息

Proc Biol Sci. 2009 Mar 22;276(1659):1137-46. doi: 10.1098/rspb.2008.1597.

Abstract

California killifish (Fundulus parvipinnis) infected with the brain-encysting trematode Euhaplorchis californiensis display conspicuous swimming behaviours rendering them more susceptible to predation by avian final hosts. Heavily infected killifish grow and reproduce normally, despite having thousands of cysts inside their braincases. This suggests that E. californiensis affects only specific locomotory behaviours. We hypothesised that changes in the serotonin and dopamine metabolism, essential for controlling locomotion and arousal may underlie this behaviour modification. We employed micropunch dissection and HPLC to analyse monoamine and monoamine metabolite concentrations in the brain regions of uninfected and experimentally infected fish. The parasites exerted density-dependent changes in monoaminergic activity distinct from those exhibited by fish subjected to stress. Specifically, E. californiensis inhibited a normally occurring, stress-induced elevation of serotonergic metabolism in the raphae nuclei. This effect was particularly evident in the experimentally infected fish, whose low-density infections were concentrated on the brainstem. Furthermore, high E. californiensis density was associated with increased dopaminergic activity in the hypothalamus and decreased serotonergic activity in the hippocampus. In conclusion, the altered monoaminergic metabolism may explain behavioural differences leading to increased predation of the infected killifish by their final host predators.

摘要

感染了寄生于脑部的吸虫加州真雀鲷吸虫(Euhaplorchis californiensis)的加州鳉鱼(Fundulus parvipinnis)表现出明显的游动行为,这使它们更容易被鸟类终末宿主捕食。尽管脑壳内有数千个囊肿,但重度感染的鳉鱼仍能正常生长和繁殖。这表明加州真雀鲷吸虫仅影响特定的运动行为。我们推测,控制运动和觉醒所必需的血清素和多巴胺代谢变化可能是这种行为改变的基础。我们采用微量打孔解剖和高效液相色谱法分析未感染和实验感染鱼类脑区中的单胺和单胺代谢物浓度。寄生虫引起的单胺能活性变化与密度有关,这与遭受应激的鱼类表现出的变化不同。具体而言,加州真雀鲷吸虫抑制了中缝核中正常发生的、由应激诱导的血清素代谢升高。这种效应在实验感染的鱼类中尤为明显,其低密度感染集中在脑干。此外,高浓度的加州真雀鲷吸虫与下丘脑多巴胺能活性增加以及海马体血清素能活性降低有关。总之,单胺能代谢的改变可能解释了导致感染鳉鱼被其终末宿主捕食增加的行为差异。

相似文献

2
Brain-encysting trematodes and altered monoamine activity in naturally infected killifish Fundulus parvipinnis.
J Fish Biol. 2012 Dec;81(7):2213-22. doi: 10.1111/j.1095-8649.2012.03439.x. Epub 2012 Sep 5.
5
7
Increased surfacing behavior in longnose killifish infected by brain-encysting trematode.
J Parasitol. 2012 Oct;98(5):899-903. doi: 10.1645/GE-3170.1. Epub 2012 May 4.
9
Effects of a pesticide and a parasite on neurological, endocrine, and behavioral responses of an estuarine fish.
Aquat Toxicol. 2016 Jan;170:335-343. doi: 10.1016/j.aquatox.2015.09.010. Epub 2015 Sep 25.
10
Euhaplorchis californiensis Cercariae Exhibit Positive Phototaxis and Negative Geotaxis.
J Parasitol. 2018 Jun;104(3):329-333. doi: 10.1645/17-80. Epub 2018 Feb 27.

引用本文的文献

3
Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease.
Sci Rep. 2023 Sep 1;13(1):14363. doi: 10.1038/s41598-023-40065-0.
5
Parasite effects on receivers in animal communication: Hidden impacts on behavior, ecology, and evolution.
Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2300186120. doi: 10.1073/pnas.2300186120. Epub 2023 Jul 17.
6
Infection with an acanthocephalan helminth reduces anxiety-like behaviour in crustacean host.
Sci Rep. 2022 Dec 15;12(1):21649. doi: 10.1038/s41598-022-25484-9.
7
Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster.
PLoS Pathog. 2022 Sep 21;18(9):e1010826. doi: 10.1371/journal.ppat.1010826. eCollection 2022 Sep.
8
Invasion history shapes host transcriptomic response to a body-snatching parasite.
Mol Ecol. 2021 Sep;30(17):4321-4337. doi: 10.1111/mec.16038. Epub 2021 Jul 20.
9
Effects of the cranial parasite sp. on the behavior and physiology of puye (Jenyns, 1842).
PeerJ. 2021 Mar 22;9:e11095. doi: 10.7717/peerj.11095. eCollection 2021.

本文引用的文献

2
Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors.
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6442-7. doi: 10.1073/pnas.0608310104. Epub 2007 Apr 2.
3
Navigation within host tissues: cues for orientation of Diplostomum spathaceum (Trematoda) in fish towards veins, head and eye.
Parasitology. 2007 Jul;134(Pt 7):1013-23. doi: 10.1017/S0031182007002430. Epub 2007 Feb 22.
4
Rapid neuroendocrine responses evoked at the onset of social challenge.
Physiol Behav. 2007 Mar 16;90(4):567-75. doi: 10.1016/j.physbeh.2006.11.006. Epub 2006 Dec 20.
5
Interactions between the neural regulation of stress and aggression.
J Exp Biol. 2006 Dec;209(Pt 23):4581-9. doi: 10.1242/jeb.02565.
6
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission.
Pharmacol Ther. 2007 Feb;113(2):296-320. doi: 10.1016/j.pharmthera.2006.08.004. Epub 2006 Oct 17.
8
Altered host behaviour and brain serotonergic activity caused by acanthocephalans: evidence for specificity.
Proc Biol Sci. 2006 Dec 22;273(1605):3039-45. doi: 10.1098/rspb.2006.3618.
9
D2-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance.
J Pharmacol Exp Ther. 2007 Jan;320(1):376-85. doi: 10.1124/jpet.106.111690. Epub 2006 Sep 27.
10
The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study.
Parasitology. 2006 Nov;133(Pt 5):525-35. doi: 10.1017/S0031182006000886. Epub 2006 Aug 2.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验