Nishimiya Masaki, Matsuda Hiroshi, Imabayashi Etsuko, Kuji Ichiei, Sato Noriko
Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
Ann Nucl Med. 2008 Dec;22(10):921-7. doi: 10.1007/s12149-008-0211-7. Epub 2009 Jan 8.
Neuroimaging plays a major role in the early diagnosis of Alzheimer's disease (AD). Recent advances in voxelwise statistical analysis after anatomic standardization of images have made this early diagnosis easier and more objective than visual inspection. We present comparative observations of NEUROSTAT, statistical parametric mapping (SPM) 99, and SPM2 in the early diagnosis of AD using brain perfusion single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI).
We performed voxel-by-voxel statistical group analysis for brain perfusion SPECT and gray matter images segmented from MRI between 61 patients with very early AD and 82 age-matched healthy volunteers. Anatomic standardization was performed using NEUROSTAT, SPM99, and SPM2 using both original and common templates.
The location of significant reduction of regional cerebral blood flow (rCBF) for SPECT and gray matter concentration for MRI were identical among these three methods irrespective of the templates used. When using the original template, the significance of peak rCBF reduction in the posterior cingulate gyri was higher in SPM99 and SPM2 than that in NEUROSTAT. On the other hand, when using the common template, the significance of peak rCBF reduction in the posterior cingulate gyri was higher in NEUROSTAT and SPM2 than that in SPM99. NEUROSTAT showed almost the equal significance of peak rCBF reduction between the used templates. Almost the equal significance of reduction in gray matter concentration was observed in the parahippocampal gyri among the three methods.
NEUROSTAT, SPM99, and SPM2 showed identical location of significant reductions in rCBF and gray matter concentration in very early AD patients. Used templates for anatomic standardization are relevant to the results of voxelwise statistical analysis in SPM, less prominently in SPM2 than in SPM99, whereas irrelevant in NEUROSTAT.
神经影像学在阿尔茨海默病（AD）的早期诊断中起着重要作用。图像解剖标准化后的体素统计分析的最新进展使这种早期诊断比目视检查更容易、更客观。我们展示了使用脑灌注单光子发射计算机断层扫描（SPECT）和磁共振成像（MRI）对NEUROSTAT、统计参数映射（SPM）99和SPM2在AD早期诊断中的比较观察结果。
我们对61例极早期AD患者和82例年龄匹配的健康志愿者之间的脑灌注SPECT和从MRI分割出的灰质图像进行了逐体素统计组分析。使用NEUROSTAT、SPM99和SPM2，采用原始模板和通用模板进行解剖标准化。
无论使用何种模板，这三种方法中SPECT的局部脑血流量（rCBF）显著降低的位置以及MRI的灰质浓度显著降低的位置均相同。使用原始模板时，SPM99和SPM2中后扣带回rCBF峰值降低的显著性高于NEUROSTAT。另一方面，使用通用模板时，NEUROSTAT和SPM2中后扣带回rCBF峰值降低的显著性高于SPM99。NEUROSTAT在所使用的模板之间显示出几乎相同的rCBF峰值降低显著性。在三种方法中，海马旁回灰质浓度降低的显著性几乎相同。
NEUROSTAT、SPM99和SPM2在极早期AD患者中显示出rCBF和灰质浓度显著降低的相同位置。用于解剖标准化的模板与SPM中的体素统计分析结果相关，在SPM2中不如在SPM99中明显，而在NEUROSTAT中无关。
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